scholarly journals Isolated duodenal myeloid sarcoma associated with the CBFβ/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review

2014 ◽  
Vol 8 (3) ◽  
pp. 1261-1264 ◽  
Author(s):  
BO HUANG ◽  
PENG YOU ◽  
PING ZHU ◽  
ZUNGUO DU ◽  
BEIQIAN WU ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
Fusion Gene ◽  
Myeloid Sarcoma ◽  
Acute Myeloid

Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene

2018 ◽  
Vol 140 (2) ◽  
pp. 97-104 ◽  
Author(s):  
Leslie Naesens ◽  
Helena Devos ◽  
Friedel Nollet ◽  
Lucienne Michaux ◽  
Dominik Selleslag
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myeloid Leukemia ◽  
Tp53 Mutation ◽  
Metabolic Response ◽  
Fusion Gene ◽  
Granulocytic Sarcoma ◽  
Myeloid Sarcoma ◽  
Tumor Mass ◽  
Acute Myeloid

Introduction: Myeloid sarcoma (MS), previously known as granulocytic sarcoma or chloroma, is a rare neoplastic condition defined as a tumor mass consisting of myeloblasts or immature myeloid cells occurring at an extramedullary site. Clinical presentation is diverse and determined by a tumor mass effect or local organ dysfunction. Case Report: We report the case of a 25-year-old previously healthy male with rapidly progressive shortness of breath. A chest CT scan demonstrated a heterogenous anterosuperior mediastinal mass with pleural and pericardial invasion. A diagnosis of MS with both myeloid and lymphoid characteristics was made by pathologic, morphologic, and immunophenotypic investigation. Next generation analysis revealed a pathogenic TP53 mutation (c.1035_1036insCT, p.Glu346Leufs*25). After 4 cycles of chemotherapy only a partial metabolic response and tumor size reduction was obtained. A pretransplant bone marrow biopsy revealed the progression of disease to acute myeloid leukemia. Cytogenetic analysis demonstrated a t(10; 11)(p12;q21). Fluorescence in situ hybridization confirmed the presence of a PICALM-MLLT10 fusion gene. Conclusion: MS with a mediastinal localization is rare and often misdiagnosed as malignant lymphoma. Acute leukemia harboring a PICALM-MLLT10 fusion gene is characterized by a mixed T cell and myeloid phenotype. The rearrangement is a rare recurrent translocation associated with specific clinical features, as illustrated in this case report.

scholarly journals Acute myeloid leukemia with t(7;21)(p22;q22) and 5q deletion: a case report and literature review

2014 ◽  
Vol 3 (1) ◽  
pp. 8 ◽  
Author(s):  
Jianling Ji ◽  
Eric Loo ◽  
Sheeja Pullarkat ◽  
Lynn Yang ◽  
Carlos A Tirado
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
5Q Deletion ◽  
Acute Myeloid

scholarly journals Isolated Gastric Myeloid Sarcoma: A Case Report and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Pankit Vachhani ◽  
Prithviraj Bose
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myeloid Leukemia ◽  
Bone Marrow Involvement ◽  
Myeloid Sarcoma ◽  
Review Of The Literature ◽  
Aged Woman ◽  
Middle Aged Woman ◽  
Acute Myeloid

Myeloid sarcoma represents the proliferation of myeloblasts of acute myeloid leukemia (AML) at extramedullary sites. While extramedullary involvement in AML is uncommon in itself, isolated myeloid sarcomas, that is, myeloid sarcomas without any bone marrow involvement, are extremely rare and pose a diagnostic and therapeutic challenge. Here, we present the case of a middle-aged woman with isolated myeloid sarcoma in the stomach—an organ seldom involved by this disease. Additionally, the literature on the epidemiology, diagnosis, pathology, prognosis, and therapeutic options in myeloid sarcomas has been reviewed.

scholarly journals Ocular Granulocytic Sarcoma: A Case Report and Literature Review of Ocular Extramedullary Acute Myeloid Leukemia

2013 ◽  
Vol 13 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Maro Ohanian ◽  
Gautam Borthakur ◽  
Alfonso Quintas-Cardama ◽  
Michael Mathisen ◽  
Jorge E. Cortés ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
Granulocytic Sarcoma ◽  
Acute Myeloid

scholarly journals Acute Myeloid Leukemia with Translocation (8;16)(p11;p13): A Distinct Syndrome– Case Report and Literature Review

2017 ◽  
Vol 03 (02) ◽  
Author(s):  
Naomi Dempsey ◽  
Moh d Khushmann ◽  
Peter Hosein ◽  
Clifford Blieden ◽  
Jennifer Chapman Fredricks ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
Acute Myeloid

Acute myeloid leukemia following radioiodine therapy: Case report and brief literature review

2016 ◽  
Vol 5 (3) ◽  
pp. 246 ◽  
Author(s):  
Ruchi Gupta ◽  
Garima Aggarwal ◽  
Khaliqur Rahman ◽  
ManishKumar Singh ◽  
Soniya Nityanand
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
Radioiodine Therapy ◽  
Acute Myeloid

scholarly journals Liver Abscess by Aspergillus and Enterococcus faecium in a Patient with Acute Myeloid Leukemia: A Case Report and Literature Review

2011 ◽  
Vol 43 (4) ◽  
pp. 377 ◽  
Author(s):  
Kyung-Wook Hong ◽  
Jae-Cheol Kwon ◽  
Hyun Ji Chun ◽  
Dong-Gun Lee ◽  
Hee-Je Kim ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Literature Review ◽  
Liver Abscess ◽  
Enterococcus Faecium ◽  
Myeloid Leukemia ◽  
Acute Myeloid
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