scholarly journals 786-0 Renal cancer cell line-derived exosomes promote 786-0 cell migration and invasion in vitro

2014 ◽  
Vol 7 (5) ◽  
pp. 1576-1580 ◽  
Author(s):  
GANG CHEN ◽  
YAO ZHANG ◽  
XIAOHOU WU
Keyword(s):  
Cell Migration ◽  
Cell Line ◽  
Cancer Cell ◽  
Renal Cancer ◽  
Cancer Cell Line ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Renal Cancer Cell

scholarly journals Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line

2016 ◽  
Vol 49 (1) ◽  
Author(s):  
Kurt Buchegger ◽  
Carmen Ili ◽  
Ismael Riquelme ◽  
Pablo Letelier ◽  
Alejandro H. Corvalán ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals High content screen for identifying small-molecule LC3B-localization modulators in a renal cancer cell line

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Likhitha Kolla ◽  
David S. Heo ◽  
Daniel P. Rosenberg ◽  
Sara A. Barlow ◽  
Anna A. Maximova ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Renal Cancer ◽  
Small Molecule ◽  
Cancer Cell Line ◽  
Renal Cancer Cell

Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway

2017 ◽  
Vol 474 (22) ◽  
pp. 3733-3746 ◽  
Author(s):  
Fatima Lahdaoui ◽  
Mathieu Messager ◽  
Audrey Vincent ◽  
Flora Hec ◽  
Anne Gandon ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastrointestinal Cancer ◽  
Tumour Growth ◽  
Cancer Cell Line ◽  
Migration And Invasion ◽  
Down Regulation

Secreted mucins are large O-glycosylated proteins that participate in the protection/defence of underlying mucosae in normal adults. Alteration of their expression is a hallmark of numerous epithelial cancers and has often been correlated to bad prognosis of the tumour. The secreted mucin MUC5B is overexpressed in certain subtypes of gastric and intestinal cancers, but the consequences of this altered expression on the cancer cell behaviour are not known. To investigate the role of MUC5B in carcinogenesis, its expression was knocked-down in the human gastric cancer cell line KATO-III and in the colonic cancer cell line LS174T by using transient and stable approaches. Consequences of MUC5B knocking-down on cancer cells were studied with respect to in vitro proliferation, migration and invasion, and in vivo on tumour growth using a mouse subcutaneous xenograft model. Western blotting, luciferase assay and qRT–PCR were used to identify proteins and signalling pathways involved. In vitro MUC5B down-regulation leads to a decrease in proliferation, migration and invasion properties in both cell lines. Molecular mechanisms involved the alteration of β-catenin expression, localization and activity and decreased expression of several of its target genes. In vivo xenografts of MUC5B-deficient cells induced a decrease in tumour growth when compared with MUC5B-expressing Mock cells. Altogether, the present study shows that down-regulation of MUC5B profoundly alters proliferation, migration and invasion of human gastrointestinal cancer cells and that these alterations may be, in part, mediated by the Wnt/β-catenin pathway emphasizing the potential of MUC5B as an actor of gastrointestinal carcinogenesis.

The effect of clusterin suppression in combination with cisplatin on renal cancer cell line

2002 ◽  
Vol 1 (1) ◽  
pp. 142
Author(s):  
Changho Lee ◽  
Cheol Kwak ◽  
Park Moon Soo ◽  
Yeon Yoon Soo ◽  
Eunsik Lee ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Renal Cancer ◽  
Cancer Cell Line ◽  
Renal Cancer Cell
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