scholarly journals Effects of photodynamic hyperthermal therapy with indocyanine green on tumor growth in a colon 26 tumor-bearing mouse model

2014 ◽  
Vol 7 (4) ◽  
pp. 1147-1150 ◽  
Author(s):  
MASAKI ONOYAMA ◽  
KAZUO AZUMA ◽  
TAKESHI TSUKA ◽  
TOMOHIRO IMAGAWA ◽  
TOMOHIRO OSAKI ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Indocyanine Green ◽  
Tumor Bearing Mouse ◽  
Colon 26 ◽  
Tumor Bearing

scholarly journals Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2337-2348 ◽  
Author(s):  
Kazuo Azuma ◽  
Toshitsugu Ishihara ◽  
Hiroyuki Nakamoto ◽  
Takao Amaha ◽  
Tomohiro Osaki ◽  
...  
Keyword(s):  
Mouse Model ◽  
Oral Administration ◽  
Tumor Growth ◽  
Survival Time ◽  
Tumor Bearing Mouse ◽  
Growth And Survival ◽  
Tumor Bearing ◽  
Cladosiphon Okamuranus

scholarly journals Antitumor activity of melinjo ( Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon‐26 tumor‐bearing mouse model in vivo

2015 ◽  
Vol 4 (11) ◽  
pp. 1767-1780 ◽  
Author(s):  
Narayanan K. Narayanan ◽  
Kazuhiro Kunimasa ◽  
Yukio Yamori ◽  
Mari Mori ◽  
Hideki Mori ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mouse Model ◽  
Seed Extract ◽  
Tumor Bearing Mouse ◽  
Colon 26 ◽  
Murine Tumor ◽  
Tumor Bearing ◽  
Gnetum Gnemon

scholarly journals Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model

2021 ◽  
Author(s):  
Yeu-Sheng Tyan ◽  
Yen-Po Lee ◽  
Hui-Yen Chuang ◽  
Wei-Hsun Wang ◽  
Jeng-Jong Hwang
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Fatty Acid ◽  
Mouse Model ◽  
Tumor Growth ◽  
Fatty Acid Synthase ◽  
Synergistic Effects ◽  
Growth Delay ◽  
Tumor Bearing Mouse ◽  
Tumor Bearing

Androgen deprivation therapy (ADT) is one of the typical treatments used for patients with prostate cancer (PCa). ADT, however, may fail when PCa develops castration-resistance. Fatty acid synthase (FASN), a critical enzyme involved in fatty acid synthesis, is found to be upregulated in PCa. Since enzalutamide and ADT are frequently used for the treatment of PCa, this study aimed to unravel the underlying mechanism of combination of orlistat, a FASN inhibitor, and enzalutamide using PC3 cell line; and orlistat and castration in PC3 tumor-bearing animal model. Cytotoxicity was determined by AlamarBlue assay. Drug effects on the cell cycle and protein expressions were assayed by the flow cytometry and Western blot. Electromobility shift assay was used to evaluate the NF-κB activity. The tumor growth delay, expressions of the signaling–related proteins, and histopathology post treatments of orlistat and castration were evaluated in PC3 tumor-bearing mouse model. The results showed that orlistat arrested the PC3 cells at the G1 phase of the cell cycle and enhanced the cytotoxic effects of enzalutamide synergistically. Pretreatment with orlistat combined with castration inhibited the tumor growth significantly compared with those of castration and orlistat treatments alone in PC3 tumor-bearing mice. Combination treatment reduced both fatty acid synthase and NF-κB activities and their downstream effector proteins. The present study demonstrated the synergistic effects of orlistat combined with enzalutamide in vitro and castration in vivo on human prostate cancer.

scholarly journals Radiation-induced lung fibrosis in a tumor-bearing mouse model is associated with enhanced Type-2 immunity

2015 ◽  
Vol 57 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Jing Chen ◽  
Yacheng Wang ◽  
Zijie Mei ◽  
Shimin Zhang ◽  
Jie Yang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lung Fibrosis ◽  
Tumor Bearing Mouse ◽  
Tumor Bearing ◽  
Type 2 Immunity ◽  
Radiation Induced

scholarly journals Evaluation of Injectable Chitosan-based Co-cross-linking Hydrogel for Local Delivery of 188Re-LIPO-DOX to Breast-tumor-bearing Mouse Model

2018 ◽  
Vol 38 (8) ◽  
pp. 4651-4659 ◽  
Author(s):  
FENG-YUN J. HUANG ◽  
CHENG-CHIEN HUNG ◽  
CHIEN-WEN CHANG ◽  
JIUNN-HSING CHAO ◽  
BOR-TSUNG HSIEH
Keyword(s):  
Mouse Model ◽  
Breast Tumor ◽  
Local Delivery ◽  
Cross Linking ◽  
Tumor Bearing Mouse ◽  
Tumor Bearing

Abstract 696: Anti-NRP1 tumor uptake is impacted by normal tissue sinks in a tumor bearing mouse model

2010 ◽  
Author(s):  
Daniela Bumbaca ◽  
Charles A. Boswell ◽  
Hong Xiang ◽  
Ruediger Port ◽  
Michelle Schweiger ◽  
...  
Keyword(s):  
Mouse Model ◽  
Normal Tissue ◽  
Tumor Bearing Mouse ◽  
Tumor Uptake ◽  
Tumor Bearing

The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast tumor bearing mouse model

2015 ◽  
Vol 3 (8) ◽  
pp. 1518-1528 ◽  
Author(s):  
Yang Du ◽  
Wenzhi Ren ◽  
Yaqian Li ◽  
Qian Zhang ◽  
Leyong Zeng ◽  
...  
Keyword(s):  
Side Effects ◽  
Mouse Model ◽  
Breast Tumor ◽  
Breast Tumors ◽  
Tumor Bearing Mouse ◽  
Tumor Bearing

TiO2–PEG–DOX nanoparticles improve the chemotherapeutic effects of doxorubicin in orthotopic breast tumors and minimize the DOX side effects.

scholarly journals A high-selectivity fluorescent probe for hypoxia imaging in cells and a tumor-bearing mouse model

The Analyst ◽  
2020 ◽  
Vol 145 (4) ◽  
pp. 1389-1395 ◽  
Author(s):  
Yue Wang ◽  
Xiaoyue Han ◽  
Xia Zhang ◽  
Li Zhang ◽  
Lingxin Chen
Keyword(s):  
Mouse Model ◽  
Fluorescent Probe ◽  
High Selectivity ◽  
Tumor Bearing Mouse ◽  
Hypoxia Imaging ◽  
Two Photon ◽  
Tumor Bearing ◽  
In Cells

A two-photon fluorescent probe, hTP-NNO2, is developed for hypoxia evaluation via NTR detection.

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