scholarly journals Synergistic effect of ginsenoside Rg3 with verapamil on the modulation of multidrug resistance in human acute myeloid leukemia cells

2014 ◽  
Vol 7 (4) ◽  
pp. 1265-1269 ◽  
Author(s):  
SUNG SU KIM ◽  
SIN SEONG ◽  
SUNG YOUNG KIM
Keyword(s):  
Acute Myeloid Leukemia ◽  
Multidrug Resistance ◽  
Synergistic Effect ◽  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Ginsenoside Rg3 ◽  
Human Acute Myeloid Leukemia ◽  
Acute Myeloid Leukemia Cells ◽  
Acute Myeloid

scholarly journals Piceatannol, a Structural Analog of Resveratrol, Is an Apoptosis Inducer and a Multidrug Resistance Modulator in HL-60 Human Acute Myeloid Leukemia Cells

2021 ◽  
Vol 22 (19) ◽  
pp. 10597
Author(s):  
Kamila Siedlecka-Kroplewska ◽  
Agata Wrońska ◽  
Zbigniew Kmieć
Keyword(s):  
Acute Myeloid Leukemia ◽  
Multidrug Resistance ◽  
Myeloid Leukemia ◽  
Chemotherapeutic Agent ◽  
Chemotherapeutic Agents ◽  
Leukemia Cells ◽  
Term Survival ◽  
Human Acute Myeloid Leukemia ◽  
Acute Myeloid Leukemia Cells ◽  
Acute Myeloid

Acute myeloid leukemia is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Despite recent advances in the treatment of this disease, the prognosis and overall long-term survival for patients remain poor, which drives the search for new chemotherapeutics and treatment strategies. Piceatannol, a polyphenolic compound present in grapes and wine, appears to be a promising chemotherapeutic agent in the treatment of leukemia. The aim of the present study was to examine whether piceatannol induces autophagy and/or apoptosis in HL-60 human acute myeloid leukemia cells and whether HL-60 cells are able to acquire resistance to piceatannol toxicity. We found that piceatannol at the IC90 concentration of 14 µM did not induce autophagy in HL-60 cells. However, it induced caspase-dependent apoptosis characterized by phosphatidylserine externalization, disruption of the mitochondrial membrane potential, caspase-3 activation, internucleosomal DNA fragmentation, PARP1 cleavage, chromatin condensation, and fragmentation of cell nuclei. Our findings also imply that HL-60 cells are able to acquire resistance to piceatannol toxicity via mechanisms related to MRP1 activity. Our results suggest that the use of piceatannol as a potential chemotherapeutic agent may be associated with the risk of multidrug resistance, warranting its use in combination with other chemotherapeutic agents.

Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells

2015 ◽  
Vol 43 (7) ◽  
pp. 524-533.e1 ◽  
Author(s):  
Ichiro Kawashima ◽  
Toru Mitsumori ◽  
Yumi Nozaki ◽  
Takeo Yamamoto ◽  
Yuki Shobu-Sueki ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Negative Regulation ◽  
Leukemia Cells ◽  
Ampk Pathway ◽  
Human Acute Myeloid Leukemia ◽  
Acute Myeloid Leukemia Cells ◽  
Acute Myeloid
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