scholarly journals Mechanisms underlying the biological changes induced by isocitrate dehydrogenase-1 mutation in glioma cells

2014 ◽  
Vol 7 (3) ◽  
pp. 651-657 ◽  
Author(s):  
JU-BO WANG ◽  
DAN-FENG DONG ◽  
KE GAO ◽  
MAO-DE WANG
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Glioma Cells ◽  
Isocitrate Dehydrogenase 1

Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death

APOPTOSIS ◽  
2013 ◽  
Vol 18 (11) ◽  
pp. 1416-1425 ◽  
Author(s):  
Isabelle Vanessa Mohrenz ◽  
Patrick Antonietti ◽  
Stefan Pusch ◽  
David Capper ◽  
Jörg Balss ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Isocitrate Dehydrogenase ◽  
Glioma Cells ◽  
Isocitrate Dehydrogenase 1

scholarly journals An R132H Mutation in Isocitrate Dehydrogenase 1 Enhances p21 Expression and Inhibits Phosphorylation of Retinoblastoma Protein in Glioma Cells

2013 ◽  
Vol 53 (10) ◽  
pp. 645-654 ◽  
Author(s):  
Satsuki MIYATA ◽  
Masashi URABE ◽  
Akira GOMI ◽  
Mutsumi NAGAI ◽  
Takashi YAMAGUCHI ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Glioma Cells ◽  
Retinoblastoma Protein ◽  
Isocitrate Dehydrogenase 1 ◽  
R132h Mutation

Structural analysis of oncogenic mutation of isocitrate dehydrogenase 1

2016 ◽  
Vol 12 (7) ◽  
pp. 2276-2287 ◽  
Author(s):  
Vidya Rajendran
Keyword(s):  
Structural Analysis ◽  
Isocitrate Dehydrogenase ◽  
Isocitrate Dehydrogenase 1 ◽  
Oncogenic Mutation

Arginine to histidine mutation at position 132 (R132H) in isocitrate dehydrogenase 1 (IDH1) led to reduced affinity of the respective enzymes for isocitrate and increased affinity for α-ketoglutarate (AKG) and NADPH.

An olive oil phenolic is a new chemotype of mutant isocitrate dehydrogenase 1 (IDH1) inhibitors

2018 ◽  
Vol 40 (1) ◽  
pp. 27-40 ◽  
Author(s):  
Sara Verdura ◽  
Elisabet Cuyàs ◽  
Jesús Lozano-Sánchez ◽  
Cristian Bastidas-Velez ◽  
Laura Llorach-Parés ◽  
...  
Keyword(s):  
Olive Oil ◽  
Isocitrate Dehydrogenase ◽  
Isocitrate Dehydrogenase 1

scholarly journals Isocitrate dehydrogenase 1 and 2 mutations, 2‐hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia

Cancer ◽  
2018 ◽  
Vol 125 (4) ◽  
pp. 541-549 ◽  
Author(s):  
Andrew M. Brunner ◽  
Donna S. Neuberg ◽  
Seth A. Wander ◽  
Hossein Sadrzadeh ◽  
Karen K. Ballen ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Isocitrate Dehydrogenase ◽  
Myeloid Leukemia ◽  
Newly Diagnosed ◽  
Standard Chemotherapy ◽  
Isocitrate Dehydrogenase 1 ◽  
Acute Myeloid
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