scholarly journals O-desmethylangolensin inhibits the proliferation of human breast cancer MCF-7 cells by inducing apoptosis and promoting cell cycle arrest

2013 ◽  
Vol 6 (6) ◽  
pp. 1784-1788 ◽  
Author(s):  
EUN JEONG CHOI ◽  
GUN-HEE KIM
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Cycle Arrest ◽  
Mcf 7

scholarly journals Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2777 ◽  
Author(s):  
Wonhyoung Park ◽  
Sunwoo Park ◽  
Gwonhwa Song ◽  
Whasun Lim
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Er Stress ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Cycle Arrest ◽  
Mcf 7

Background: Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Although, recently, the number of pathological studies of breast cancer have increased, it is necessary to identify a novel compound that targets multiple signaling pathways involved in breast cancer. Methods: The effects of osthole on cell viability, apoptosis, mitochondria-mediated apoptosis, production of reactive oxygen species (ROS), and endoplasmic reticulum (ER) stress proteins of BT-474 and MCF-7 breast cancer cell lines were investigated. Signal transduction pathways in both cells in response to osthole were determined by western blot analyses. Results: Here, we demonstrated that osthole inhibited cellular proliferation and induced cell cycle arrest through modulation of cell cycle regulatory genes in BT-474 and MCF-7 cells. Additionally, osthole induced loss of mitochondrial membrane potential (MMP), intracellular calcium imbalance, and ER stress. Moreover, osthole induced apoptosis by activating the pro-apoptotic protein, Bax, in both cell lines. Osthole regulated phosphorylation of signaling proteins such as Akt and ERK1/2 in human breast cancer cells. Furthermore, osthole-induced activation of JNK protein-mediated apoptosis in both cell lines. Conclusions: Collectively, the results of the present study indicated that osthole may ameliorate breast cancer and can be a promising therapeutic agent for treatment of breast cancer.

Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines

2020 ◽  
pp. 1-19
Author(s):  
Daniel Abraham Espinosa-Paredes ◽  
Jorge Cornejo-Garrido ◽  
Mario Adán Moreno-Eutimio ◽  
Oswaldo Pablo Martínez-Rodríguez ◽  
María Eugenia Jaramillo-Flores ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Echinacea Angustifolia ◽  
Cycle Arrest ◽  
Mcf 7
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