scholarly journals Spica Prunellae extract inhibits the proliferation of human colon carcinoma cells via the regulation of the cell cycle

2013 ◽  
Vol 6 (4) ◽  
pp. 1123-1127 ◽  
Author(s):  
WEI LIN ◽  
LIANGPU ZHENG ◽  
QUNCHUAN ZHUANG ◽  
ALING SHEN ◽  
LIYA LIU ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma

Radiosensitization by pemetrexed of human colon carcinoma cells in different cell cycle phases

2003 ◽  
Vol 57 (1) ◽  
pp. 289-292 ◽  
Author(s):  
Marc Bischof ◽  
Peter Huber ◽  
Clemens Stoffregen ◽  
Michael Wannenmacher ◽  
Klaus-Josef Weber
Keyword(s):  
Cell Cycle ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Cell Cycle Phases

Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1

2005 ◽  
Vol 1726 (3) ◽  
pp. 328-335 ◽  
Author(s):  
Swadesh K. Das ◽  
Takashi Hashimoto ◽  
Kazuo Shimizu ◽  
Tatsushi Yoshida ◽  
Toshiyuki Sakai ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
G1 Phase ◽  
Colon Carcinoma Cells ◽  
Cycle Arrest ◽  
Human Colon Carcinoma

scholarly journals Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells.

1995 ◽  
Vol 15 (5) ◽  
pp. 2374-2382 ◽  
Author(s):  
J Park ◽  
C A Cartwright
Keyword(s):  
Cell Cycle ◽  
Colon Carcinoma ◽  
Human Colon ◽  
T Antigen ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Polyomavirus Middle T Antigen ◽  
Middle T Antigen ◽  
Ht 29

Src and Yes protein-tyrosine kinase activities are elevated in malignant and premalignant tumors of the colon. To determine whether Src activity is elevated throughout the human colon carcinoma cell cycle as it is in polyomavirus middle T antigen- or F527 Src-transformed cells, and whether Yes activity, which is lower than that of Src in the carcinoma cells, is regulated differently, we measured their activities in cycling cells. We observed that the activities of both kinases were higher throughout all phases of the HT-29 colon carcinoma cell cycle than in corresponding phases of the fibroblast cycle. In addition, during mitosis of HT-29 cells, Src specific activity increased two- to threefold more, while Yes activity and abundance decreased threefold. The decreased steady-state protein levels of Yes during mitosis appeared to be due to both decreased synthesis and increased degradation of the protein. Inhibition of tyrosine but not serine/threonine phosphatases abolished the mitotic activation of Src. Mitotic Src was phosphorylated at novel serine and threonine sites and dephosphorylated at Tyr-527. Two cellular proteins (p160 and p180) were phosphorylated on tyrosine only during mitosis. Tyrosine phosphorylation of several other proteins decreased during mitosis. Thus, Src in HT-29 colon carcinoma cells, similar to Src complexed to polyomavirus middle T antigen or activated by mutation at Tyr-527, is highly active in all phases of the cell cycle. Moreover, Src activity further increases during mitosis, whereas Yes activity and abundance decrease. Thus, Src and Yes appear to be regulated differently during mitosis of HT-29 colon carcinoma cells.

Lack of carotenoid effects on cell proliferation and expression of cell cycle regulating factors in human colon carcinoma cells

2001 ◽  
Vol 120 (5) ◽  
pp. A677
Author(s):  
Hardi Luehrs ◽  
Juergen Schauber ◽  
Kerstin Backhaus ◽  
Elisabeth Kelber ◽  
Ralph Melcher ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma
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