scholarly journals microRNA-199a is able to reverse cisplatin resistance in human ovarian cancer cells through the inhibition of mammalian target of rapamycin

2013 ◽  
Vol 6 (3) ◽  
pp. 789-794 ◽  
Author(s):  
ZHONGXIAN WANG ◽  
ZHOU TING ◽  
YA LI ◽  
GANG CHEN ◽  
YUNPING LU ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer

Lupeol Inhibits Proliferation and Promotes Apoptosis of Ovarian Cancer Cells by Inactivating Phosphoinositide-3-Kinase/Protein Kinase B/ Mammalian Target of Rapamycin Pathway

2020 ◽  
Vol 19 (2) ◽  
pp. 206-210
Author(s):  
Feng Chen ◽  
Bei Zhang
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Protein Kinase ◽  
Cell Viability ◽  
Cancer Cells ◽  
Protein Kinase B ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Ovarian Cancer Cells ◽  
Phosphoinositide 3 Kinase

Lupeol exhibits multiple pharmacological activities including, anticancerous, anti-inflammatory, and antioxidant. The aim of this study was to explore the anticancerous activity of lupeol on ovarian cancer cells and examine its mechanism of action. To this end, increasing concentrations of lupeol on cell viability, cell cycle, and apoptosis in Caov-3 cells were evaluated. Lupeol inhibited cell viability, induced G1 phase arrest in cell cycle, increased cell apoptosis, and inhibited the ratio of phospho-Akt/protein kinase B and phospho-mammalian target of rapamycin/mammalian target of rapamycin. In conclusion, these data suggest that lupeol may play a therapeutic role in ovarian cancer.

MiR-489 modulates cisplatin resistance in human ovarian cancer cells by targeting Akt3

2014 ◽  
Vol 25 (7) ◽  
pp. 799-809 ◽  
Author(s):  
Huijuan Wu ◽  
Zhenghua Xiao ◽  
Hua Zhang ◽  
Ke Wang ◽  
Wenxin Liu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer

scholarly journals Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells

Neoplasma ◽  
2015 ◽  
Vol 62 (03) ◽  
pp. 432-438 ◽  
Author(s):  
F. WANG ◽  
J. ZHOU ◽  
X. XIE ◽  
J. HU ◽  
L. CHEN ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

p62/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins

2011 ◽  
Vol 47 (10) ◽  
pp. 1585-1594 ◽  
Author(s):  
Huimei Yu ◽  
Jing Su ◽  
Ye Xu ◽  
Jinsong Kang ◽  
Hongyan Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Ubiquitinated Proteins
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