scholarly journals Immune response, clinical outcome and safety of dendritic cell vaccine in combination with cytokine-induced killer cell therapy in cancer patients

2013 ◽  
Vol 6 (2) ◽  
pp. 537-541 ◽  
Author(s):  
YU CUI ◽  
XUEJING YANG ◽  
WEI ZHU ◽  
JIALI LI ◽  
XIAOJING WU ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cell ◽  
Clinical Outcome ◽  
Cell Therapy ◽  
Cancer Patients ◽  
Killer Cell ◽  
Dendritic Cell Vaccine ◽  
Cell Vaccine

scholarly journals Dendritic cell vaccine and cytokine-induced killer cell therapy for the treatment of advanced non-small cell lung cancer

2016 ◽  
Vol 11 (4) ◽  
pp. 2605-2610 ◽  
Author(s):  
LIHONG ZHANG ◽  
XUEJING YANG ◽  
ZHEN SUN ◽  
JIALI LI ◽  
HUI ZHU ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dendritic Cell ◽  
Cell Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Killer Cell ◽  
Dendritic Cell Vaccine ◽  
Small Cell ◽  
Cell Vaccine ◽  
Small Cell Lung

scholarly journals Influence of Immunotherapy with Autologous Dendritic Cells on Innate and Adaptive Immune Response in Cancer

2013 ◽  
Vol 7 ◽  
pp. CMO.S12268 ◽  
Author(s):  
Bruna F. Matias ◽  
Tânia M. De Oliveira ◽  
Cláudia M. Rodrigues ◽  
Douglas R. Abdalla ◽  
Letícia Montes ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Immune Response ◽  
Dendritic Cell ◽  
B Lymphocytes ◽  
Dendritic Cell Vaccine ◽  
Cell Vaccine ◽  
Enzyme Linked Immunosorbent Assay ◽  
Autologous Dendritic Cell ◽  
Tnf Α ◽  
Ifn Γ

The objective of this study was to evaluate some of the mechanisms involved in the activation of the immune system in patients with advanced-stage cancer (n = 7) who received an autologous dendritic cell vaccine. We examined the immune response mediated by macrophages (CD14+), natural killer cells (CD56+), and B lymphocytes (CD19+) by flow cytometry and assessed the expression of Th1 (IFN-γ, TNF-α, IL-2, and IL-12), Th2 (IL-4), and Treg (TGF-β) cytokines by flow cytometry and an enzyme-linked immunosorbent assay. The CD14+ TNF-α+ population was significantly increased ( P < 0.04) when patients received the vaccine; IL-2 expression in both NK cells and in B lymphocytes was increased after a transient initial increase showed a nearly significant decrease ( P < 0.07 and P < 0.06 respectively), whereas the CD19+ and CD56+ populations did not show significant changes. Dendritic cell-based immunotherapy led to increased secretion of IFN-γ and IL-12 and reduced secretion of TGF-β. In conclusion, it is likely that the autologous dendritic cell vaccine stimulated the immune cells from the peripheral blood of patients with cancer and generally increased the production of Th1 cytokines, which are related to immunomodulatory responses against cancer.

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