scholarly journals Epigenetic regulation of the human telomerase reverse transciptase gene: A potential therapeutic target for the treatment of leukemia (Review)

2013 ◽  
Vol 6 (2) ◽  
pp. 317-322 ◽  
Author(s):  
XINBING SUI ◽  
NA KONG ◽  
ZHANGGUI WANG ◽  
HONGMING PAN
Keyword(s):  
Epigenetic Regulation ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Human Telomerase

scholarly journals The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1377
Author(s):  
Yonggang Pei ◽  
Erle S. Robertson
Keyword(s):  
Virus Infection ◽  
Viral Infection ◽  
Epigenetic Regulation ◽  
Targeted Therapies ◽  
Therapeutic Target ◽  
Human Herpesvirus ◽  
Viral Diseases ◽  
Herpesvirus Infection ◽  
Potential Therapeutic Target ◽  
The Status

Epigenetics is a versatile player in manipulating viral infection and a potential therapeutic target for the treatment of viral-induced diseases. Both epigenetics and metabolism are crucial in establishing a highly specific transcriptional network, which may promote or suppress virus infection. Human herpesvirus infection can induce a broad range of human malignancies and is largely dependent on the status of cellular epigenetics as well as its related metabolism. However, the crosstalk between epigenetics and metabolism during herpesvirus infection has not been fully explored. Here, we describe how epigenetic regulation of cellular metabolism affects herpesvirus infection and induces viral diseases. This further highlights the importance of epigenetics and metabolism during viral infection and provides novel insights into the development of targeted therapies.

Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease

2016 ◽  
Vol 22 (10) ◽  
pp. 1305-1311 ◽  
Author(s):  
Juan Camilo Jurado-Coronel ◽  
Marco Avila-Rodriguez ◽  
Francisco Capani ◽  
Janneth Gonzalez ◽  
Valentina Echeverria Moran ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Therapeutic Target ◽  
Acetylcholine Receptors ◽  
Potential Therapeutic Target ◽  
Nicotinic Acetylcholine
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