scholarly journals Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report

2013 ◽  
Vol 6 (2) ◽  
pp. 448-452 ◽  
Author(s):  
SHIZHI HE ◽  
PINGDONG LI ◽  
XIAOHONG CHEN ◽  
ZHENKUN YU
Keyword(s):  
Ovarian Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Cancer Patient ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Lymph Node Metastases ◽  
Ovarian Cancer Patient ◽  
Supraclavicular Lymph Node ◽  
Node Metastases

scholarly journals Optical Quantification of Cellular Mass, Volume, and Density of Circulating Tumor Cells Identified in an Ovarian Cancer Patient

2012 ◽  
Vol 2 ◽  
Author(s):  
Kevin G. Phillips ◽  
Carmen Ruiz Velasco ◽  
Julia Li ◽  
Anand Kolatkar ◽  
Madelyn Luttgen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patient ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Ovarian Cancer Patient ◽  
Mass Volume

scholarly journals Supraclavicular lymph node metastases from distant primary tumors: Case reports and review of the literature

2021 ◽  
Vol 81 ◽  
pp. 105720
Author(s):  
Youssef Oukessou ◽  
Yassir Hammouda ◽  
Khadija El Bouhmadi ◽  
Redallah Larbi Abada ◽  
Mohamed Roubal ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Case Reports ◽  
Review Of The Literature ◽  
Supraclavicular Lymph Node ◽  
Primary Tumors ◽  
Node Metastases

236 Evaluation of PD-L1 expression in primary lung tumor and metastatic lymph nodes in the presence of immune cells

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A253-A253
Author(s):  
Chris Hansis ◽  
Xiaomei Wang ◽  
Tao Wang ◽  
Gerald Feldman
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Immune Cells ◽  
Lymph Node Metastases ◽  
Metastatic Lymph Node ◽  
Metastatic Lymph ◽  
Node Metastases

BackgroundImmunotherapies against programmed death ligand-1 (PD-L1) have been established as an effective treatment for a subset of lung cancer patients. Even though it is critical for a successful therapy to know prevalent PD-L1 expression patterns in all affected tissues, information on matching lymph node metastases and immune cells is particularly limited. The purpose of this study was thus to evaluate comparative PD-L1 expression profiles in those tissues.MethodsFDA-approved IHC assays for PD-L1 (Dako 22C3) were performed on a lung tissue array (LC814A, US Biomax) according to manufacturer’s instructions. Histopathological analysis by H-scoring was performed to determine the rate and intensity of positive tumor and immune cell staining for each of the 80 cores. The H score was calculated as follows: A total of up to 300 cells were assessed, per specimen, at 40x high-power magnification (typically over 7–10 fields). A staining level of 0–3 was then assigned to each cell, to designate the intensity of specific positive membranous-to-cytoplasmic staining. The H score was subsequently calculated as% cells staining at level 1 (x1) +% cells staining at level 2 (x2) +% cells staining at level 3 (x3) = total H score per sample. This resulted in a maximum possible H score of 300.ResultsOf the 16 adenocarcinoma tumor samples with a valid staining, 7 (44%) showed positive PD-L1 staining for tumor cells and 10 (63%) for primary immune cells. Importantly, 9 matching metastatic lymph node samples out of the 16 samples (56%) showed an increased PD-L1 H score compared to primary tumors for both tumor cells and immune cells (figure 1). Of the 15 squamous cell carcinoma samples with a valid staining, 11 (73%) showed detectable PD-L1 expression levels in the primary tumor and 12 (80%) in the primary immune cells, while 7 (47%) and 9 (60%) showed lower scores in matching metastatic lymph node tumor cells and their immune cells, respectively (figure 2). Very low or no expression of PD-L1 was detected in small cell lung cancer, as to be expected from previous studies.Abstract 236 Figure 1PD-L1 Staining in adenocarcinomaAbstract 236 Figure 2PD-L1 Staining in squamous cell carcinomaConclusionsSquamous cell carcinomas and adenocarcinomas display significant heterogeneity with regard to PD-L1 expression in associated lymph node metastases. While the reasons for this frequent discordant PD-L1 expression pattern involving both tumor and immune cells need to be investigated further, our findings may help guide the proper interpretation of PD-L1 companion diagnostic test results and subsequent therapeutic decisions.AcknowledgementsThe views in this Abstract have not been formally disseminated by the U.S. Food and Drug Administration and should not be construed to represent any agency determination or policy.

scholarly journals Pulmonary sclerosing hemangioma with lymph node metastases: A case report

2016 ◽  
Vol 30 (1) ◽  
pp. 57-63
Author(s):  
Toshihiro Ojima ◽  
Saya Miyahara ◽  
Shigeki Sugiyama ◽  
Hiroshi Kajiwara ◽  
Yoshinori Doki ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Sclerosing Hemangioma ◽  
Pulmonary Sclerosing Hemangioma ◽  
Node Metastases

scholarly journals A CASE REPORT OF DIFFUSE MALIGNANT MESOTHELIOMA WITH NECK LYMPH NODE METASTASES

2006 ◽  
Vol 67 (7) ◽  
pp. 1712-1716 ◽  
Author(s):  
Junko NAMBU ◽  
Toshikatsu FUKUDA ◽  
Yoshinori KURODA ◽  
Fumito KURANISHI ◽  
Manabu SHIMOMURA ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Malignant Mesothelioma ◽  
Lymph Node Metastases ◽  
Neck Lymph Node ◽  
Node Metastases ◽  
Neck Lymph Node Metastases ◽  
Diffuse Malignant Mesothelioma
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