scholarly journals Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

2013 ◽  
Vol 5 (5) ◽  
pp. 1541-1545 ◽  
Author(s):  
KUN-HUANG YAN ◽  
CHIH-JUNG YAO ◽  
CHI-HAO HSIAO ◽  
KE-HSUN LIN ◽  
YUNG-WEI LIN ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Ampk Signaling

Anticancer Activity of Methyl Gallate in RC-58T/h/SA#4 Primary Human Prostate Cancer Cells

2014 ◽  
Vol 43 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Soon Jae Kwon ◽  
Ju Hye Lee ◽  
Jae Yong Kim ◽  
Kwang Deog Moon ◽  
Sung Tae Yee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Methyl Gallate ◽  
Prostate Cancer Cells

scholarly journals Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ding-fang Zhang ◽  
Zhi-chun Yang ◽  
Jian-qiang Chen ◽  
Xiang-xiang Jin ◽  
Yin-da Qiu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Dna Damage ◽  
Cell Adhesion ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Castration Resistant Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Dna Damage And Repair ◽  
Castration Resistant

Abstract Background Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of death among men diagnosed with prostate cancer. Piperlongumine (PL) is a novel potential anticancer agent that has been demonstrated to exhibit anticancer efficacy against prostate cancer cells. However, the effects of PL on DNA damage and repair against CRPC have remained unclear. The aim of this study was to further explore the anticancer activity and mechanisms of action of PL against CRPC in terms of DNA damage and repair processes. Methods The effect of PL on CRPC was evaluated by MTT assay, long-term cell proliferation, reactive oxygen species assay, western blot assay, flow cytometry assay (annexin V/PI staining), β-gal staining assay and DAPI staining assay. The capacity of PL to inhibit the invasion and migration of CRPC cells was assessed by scratch-wound assay, cell adhesion assay, transwell assay and immunofluorescence (IF) assay. The effect of PL on DNA damage and repair was determined via IF assay and comet assay. Results The results showed that PL exhibited stronger anticancer activity against CRPC compared to that of taxol, cisplatin (DDP), doxorubicin (Dox), or 5-Fluorouracil (5-FU), with fewer side effects in normal cells. Importantly, PL treatment significantly decreased cell adhesion to the extracellular matrix and inhibited the migration of CRPC cells through affecting the expression and distribution of focal adhesion kinase (FAK), leading to concentration-dependent inhibition of CRPC cell proliferation and concomitantly increased cell death. Moreover, PL treatment triggered persistent DNA damage and provoked strong DNA damage responses in CRPC cells. Conclusion Collectively, our findings demonstrate that PL potently inhibited proliferation, migration, and invasion of CRPC cells and that these potent anticancer effects were potentially achieved via triggering persistent DNA damage in CRPC cells.

scholarly journals Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells

Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 609
Author(s):  
Sergey A. Dyshlovoy ◽  
Moritz Kaune ◽  
Jessica Hauschild ◽  
Malte Kriegs ◽  
Konstantin Hoffer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Mechanism Of Action ◽  
Synergistic Effects ◽  
Parp Inhibitor ◽  
Cross Resistance ◽  
Drug Candidate ◽  
Prostate Cancer Cells ◽  
Marine Alkaloid

Efficacy and mechanism of action of marine alkaloid 3,10-dibromofascaplysin (DBF) were investigated in human prostate cancer (PCa) cells harboring different levels of drug resistance. Anticancer activity was observed across all cell lines examined without signs of cross-resistance to androgen receptor targeting agents (ARTA) or taxane based chemotherapy. Kinome analysis followed by functional investigation identified JNK1/2 to be one of the molecular targets of DBF in 22Rv1 cells. In contrast, no activation of p38 and ERK1/2 MAPKs was observed. Inhibition of the drug-induced JNK1/2 activation or of the basal p38 activity resulted in increased cytotoxicity of DBF, whereas an active ERK1/2 was identified to be important for anticancer activity of the alkaloid. Synergistic effects of DBF were observed in combination with PARP-inhibitor olaparib most likely due to the induction of ROS production by the marine alkaloid. In addition, DBF intensified effects of platinum-based drugs cisplatin and carboplatin, and taxane derivatives docetaxel and cabazitaxel. Finally, DBF inhibited AR-signaling and resensitized AR-V7-positive 22Rv1 prostate cancer cells to enzalutamide, presumably due to AR-V7 down-regulation. These findings propose DBF to be a promising novel drug candidate for the treatment of human PCa regardless of resistance to standard therapy.

scholarly journals Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells

2018 ◽  
Vol 42 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Xu De Wang ◽  
Guang Yue Su ◽  
Chen Zhao ◽  
Fan Zhi Qu ◽  
Peng Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Ginseng Saponin

scholarly journals Size-Dependent Photodynamic Anticancer Activity of Biocompatible Multifunctional Magnetic Submicron Particles in Prostate Cancer Cells

Molecules ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 1187 ◽  
Author(s):  
Kyong-Hoon Choi ◽  
Ki Nam ◽  
Leszek Malkinski ◽  
Eun Choi ◽  
Jin-Seung Jung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Submicron Particles ◽  
Prostate Cancer Cells ◽  
Size Dependent

Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

2019 ◽  
Vol 85 ◽  
pp. 455-468 ◽  
Author(s):  
Rone Aparecido De Grandis ◽  
Patrick Wellington da Silva dos Santos ◽  
Katia Mara de Oliveira ◽  
Ana Rita Tomazela Machado ◽  
Alexandre Ferro Aissa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
2D And 3D
Sign in / Sign up

Export Citation Format

Share Document