scholarly journals SMC1A knockdown induces growth suppression of human lung adenocarcinoma cells through G1/S cell cycle phase arrest and apoptosis pathways in vitro

2013 ◽  
Vol 5 (3) ◽  
pp. 749-755 ◽  
Author(s):  
YI-FAN ZHANG ◽  
RUI JIANG ◽  
JIN-DONG LI ◽  
XING-YI ZHANG ◽  
PENG ZHAO ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Human Lung ◽  
Cell Cycle Phase ◽  
Cycle Phase ◽  
Phase Arrest ◽  
Adenocarcinoma Cells ◽  
Human Lung Adenocarcinoma Cells ◽  
Apoptosis Pathways ◽  
Lung Adenocarcinoma Cells

The effects of the electro-photodynamic in vitro treatment on human lung adenocarcinoma cells

2010 ◽  
Vol 79 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Jolanta Saczko ◽  
Mariola Nowak ◽  
Nina Skolucka ◽  
Julita Kulbacka ◽  
Malgorzata Kotulska
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Lung Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Human Lung Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
In Vitro Treatment

In vitro evaluation of antitumoral efficacy of catalase in combination with traditional chemotherapeutic drugs against human lung adenocarcinoma cells

Tumor Biology ◽  
2016 ◽  
Vol 37 (8) ◽  
pp. 10775-10784 ◽  
Author(s):  
Valeska Aguiar de Oliveira ◽  
Leonardo Lisbôa da Motta ◽  
Marco Antônio De Bastiani ◽  
Fernanda Martins Lopes ◽  
Carolina Beatriz Müller ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Chemotherapeutic Drugs ◽  
In Vitro Evaluation ◽  
Human Lung Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Human Lung Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells

scholarly journals Mahonia aquifolium Extracts Promote Doxorubicin Effects against Lung Adenocarcinoma Cells In Vitro

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5233 ◽  
Author(s):  
Ana Damjanović ◽  
Branka Kolundžija ◽  
Ivana Z. Matić ◽  
Ana Krivokuća ◽  
Gordana Zdunić ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Lung Adenocarcinoma ◽  
Colony Formation ◽  
Phase Distribution ◽  
Synergistic Effects ◽  
Cycle Phase ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
Mahonia Aquifolium

Mahonia aquifolium and its secondary metabolites have been shown to have anticancer potential. We performed MTT, scratch, and colony formation assays; analyzed cell cycle phase distribution and doxorubicin uptake and retention with flow cytometry; and detected alterations in the expression of genes involved in the formation of cell–cell interactions and migration using quantitative real-time PCR following treatment of lung adenocarcinoma cells with doxorubicin, M. aquifolium extracts, or their combination. MTT assay results suggested strong synergistic effects of the combined treatments, and their application led to an increase in cell numbers in the subG1 phase of the cell cycle. Both extracts were shown to prolong doxorubicin retention time in cancer cells, while the application of doxorubicin/extract combination led to a decrease in MMP9 expression. Furthermore, cells treated with doxorubicin/extract combinations were shown to have lower migratory and colony formation potentials than untreated cells or cells treated with doxorubicin alone. The obtained results suggest that nontoxic M. aquifolium extracts can enhance the activity of doxorubicin, thus potentially allowing the application of lower doxorubicin doses in vivo, which may decrease its toxic effects in normal tissues.

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