scholarly journals Antitumor activity of Endostar combined with radiation against human nasopharyngeal carcinoma in mouse xenograft models

2012 ◽  
Vol 4 (5) ◽  
pp. 976-980 ◽  
Author(s):  
JUYING ZHOU ◽  
LILI WANG ◽  
XIAOTING XU ◽  
YU TU ◽  
SONGBING QIN ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Antitumor Activity ◽  
Mouse Xenograft ◽  
Human Nasopharyngeal Carcinoma ◽  
Xenograft Models

scholarly journals OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models

2006 ◽  
Vol 66 (2) ◽  
pp. 1015-1024 ◽  
Author(s):  
Andrew J. Garton ◽  
Andrew P.A. Crew ◽  
Maryland Franklin ◽  
Andrew R. Cooke ◽  
Graham M. Wynne ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Selective Inhibitor ◽  
Mouse Xenograft ◽  
Kinase Insert Domain Receptor ◽  
Xenograft Models

scholarly journals An anti‑TROP2 monoclonal antibody TrMab‑6 exerts antitumor activity in breast cancer mouse xenograft models

2021 ◽  
Vol 46 (1) ◽  
Author(s):  
Tomohiro Tanaka ◽  
Tomokazu Ohishi ◽  
Teizo Asano ◽  
Junko Takei ◽  
Ren Nanamiya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Antitumor Activity ◽  
Mouse Xenograft ◽  
Xenograft Models

Diffusion kurtosis imaging and tumour microstructure for monitoring response to radiotherapy in human nasopharyngeal carcinoma xenografts

2020 ◽  
Vol 50 (5) ◽  
pp. 548-555
Author(s):  
Xiang Zheng ◽  
Yunbin Chen ◽  
Dechun Zheng ◽  
Youping Xiao ◽  
Jiayou Chen ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Nude Mice ◽  
Tumour Size ◽  
Diffusion Kurtosis Imaging ◽  
X Ray ◽  
Human Nasopharyngeal Carcinoma ◽  
Xenograft Models ◽  
D Values ◽  
Diffusion Kurtosis ◽  
Fractional Irradiation

Abstract Objective To investigate the correlations and feasibility of diffusion kurtosis imaging (DKI) parameters and tumour histopathology after radiotherapy in human nasopharyngeal carcinoma (NPC) xenografts on nude mice. Materials and Methods Seventy-two nude mice were used for the construction of CNE-1 (radio-insensitive) and CNE-2 (radio-sensitive) NPC xenograft models, followed by fraction irradiation at different doses of X-ray. The nude mice were randomly divided into six groups in each cell line models according to the dose of X-ray they have received and with six mice in each group. DKI scan was performed after radiation. DKI parameters, tumour histopathology and AQP-1 biomarkers were detected. One-way ANOVA and Pearson’s correlation analysis were used in statistical analysis. Results In CNE-1 and CNE-2 NPC xenografts, D values were increased (P < 0.01 and P < 0.001), while K values (P < 0.01 and P < 0.001) and tumour size (P < 0.001 and P < 0.001) were reduced during fraction irradiation. Additionally, cell density (CD) and AQP-1 expressions were decreased, and necrosis ratio (NR) was increased in CNE-2 xenografts after fraction irradiation (P < 0.001). The changes in D values were negatively correlated with tumour size (r = −0.856, P < 0.001), CD (r = −0.918, P < 0.001), AQP-1 mRNA (r = −0.856, P < 0.001) and protein (r = −0.381, P = 0.022) expressions while positively correlated with NR (r = 0.908, P < 0.001) in CNE-2 xenografts. The changes in K values were positively correlated with tumour size (r = 0.964, P < 0.001), CD (r = 0.888, P < 0.001), AQP-1 mRNA (r = 0.955, P < 0.001) and protein (r = 0.330, P = 0.049) expression levels while negatively correlated with NR (r = −0.930, P < 0.001). However, in CNE-1 xenografts, there were no correlation between DKI parameters and the expression of AQP-1. Conclusion Changes in D and K parameters after fractional irradiation are closely related with NPC cellular and pathological characteristics, especially size reduction and necrosis induction. These parameters exhibit potential abilities of monitoring the response to fractional irradiation in radio-sensitive NPC xenografts.

Antipodocalyxin Antibody chPcMab-47 Exerts Antitumor Activity in Mouse Xenograft Models of Colorectal Adenocarcinomas

2017 ◽  
Vol 36 (4) ◽  
pp. 157-162 ◽  
Author(s):  
Mika K. Kaneko ◽  
Akiko Kunita ◽  
Shinji Yamada ◽  
Takuro Nakamura ◽  
Miyuki Yanaka ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mouse Xenograft ◽  
Xenograft Models ◽  
Colorectal Adenocarcinomas
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