scholarly journals HER2 expression in renal cell carcinoma is rare and negatively correlated with that in normal renal tissue

2012 ◽  
Vol 4 (2) ◽  
pp. 194-198 ◽  
Author(s):  
HUILI WANG ◽  
CHENGYI LIU ◽  
JUN HAN ◽  
LIN ZHEN ◽  
TAO ZHANG ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Tissue ◽  
Her2 Expression ◽  
Normal Renal Tissue

299 DIFFERENTIATION BETWEEN NORMAL RENAL TISSUE AND RENAL CELL CARCINOMA (RCC) USING OCT

2010 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
K. Barwari ◽  
E. Cauberg ◽  
D.M. De Bruin ◽  
D.J. Faber ◽  
T.G. Van Leeuwen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Tissue ◽  
Normal Renal Tissue

CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue

1998 ◽  
Vol 26 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Sirpa Rintala ◽  
Teuvo L. J. Tammela ◽  
Risto Tuimala
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Tissue ◽  
Normal Renal Tissue

Measurement of progesterone receptor in human renal cell carcinoma and normal renal tissue

1983 ◽  
Vol 22 (3) ◽  
pp. 164-166 ◽  
Author(s):  
Michael W. McDonald ◽  
Ananias C. Diokno ◽  
Jan C. Seski ◽  
K. M. J. Menon
Keyword(s):  
Renal Cell Carcinoma ◽  
Progesterone Receptor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Tissue ◽  
Human Renal Cell Carcinoma ◽  
Normal Renal Tissue

Enhanced expression of ELAM-1 on endothelium of renal cell carcinoma compared to the corresponding normal renal tissue

1999 ◽  
Vol 143 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Walburgis Brenner ◽  
Gerd Hempel ◽  
Frank Steinbach ◽  
Rudolf Hohenfellner ◽  
Joachim W Thüroff
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Tissue ◽  
Normal Renal Tissue ◽  
Enhanced Expression

Prognostic significance of Ki-67 immunostaining in nonmetastatic renal cell carcinoma.

1993 ◽  
Vol 11 (9) ◽  
pp. 1804-1808 ◽  
Author(s):  
W T de Riese ◽  
W N Crabtree ◽  
E P Allhoff ◽  
M Werner ◽  
S Liedke ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Renal Tissue ◽  
Ki 67 ◽  
Fresh Tissue ◽  
Tissue Samples ◽  
Normal Renal Tissue

PURPOSE Fresh tissue samples from nonmetastatic renal cell carcinoma (RCC) patients were analyzed by Ki-67 immunostaining to determine the prognostic significance of this tumor-biologic parameter. MATERIALS AND METHODS In a prospective study, Ki-67 immunostaining was performed on frozen sections of histologically proven node-negative RCC from 58 patients operated on between 1986 and 1988 to examine the method's prognostic value and its association with other clinicopathologic parameters such as tumor stage (pT) and grade (G). RESULTS The percentage of Ki-67-positive cells (ie, the proliferation rate [PR]) of all 58 RCC tumors ranged between 1% and 23%, while normal renal tissue exhibited PRs up to 2% only. In almost all cases, the highest PRs were observed in the peripheral zone of malignant tissue close to the normal renal tissue. PR did not correlate with pT, whereas a strongly significant correlation was observed between PR and G, as well as recurrence rate. Twenty-three of 58 patients (39.6%) developed tumor recurrence. Disease-free survival was strongly associated with PR. In a multivariate analysis, G and PR were independent prognostic markers. CONCLUSION The tumor-specific PR obtained by Ki-67 labeling seems to be an independent marker to describe the proliferative activity and aggressiveness of individual tumors. This new tumor-biologic marker detects RCC patients at high risk for recurrent disease, especially in those cases with identical pT and G.

scholarly journals The Microbiome in Benign Renal Tissue and in Renal Cell Carcinoma

2019 ◽  
Vol 104 (3-4) ◽  
pp. 247-252 ◽  
Author(s):  
Stefan Heidler ◽  
Lukas Lusuardi ◽  
Stephan Madersbacher ◽  
Christa Freibauer
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Tissue

Angiogenic profile and pathological features in the prediction of clinical outcome of advanced renal cell carcinoma patients receiving sunitinib.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 458-458
Author(s):  
Maristella Bianconi ◽  
Mario Scartozzi ◽  
Luca Faloppi ◽  
Antonio Zizzi ◽  
Marco D'Anzeo ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance ◽  
Significant Snps ◽  
Renal Tissue ◽  
Response To Treatment ◽  
Nucleotide Polymorphisms ◽  
Pathological Features ◽  
Granular Cells

458 Background: Metastatic renal cell carcinoma (mRCC) ever represented a challenge in patients’ treatment, there is a wide variability in the amount and duration of response among patients. It has been previously reported how VEGF and VEGFRs SNPs could predict response to treatment with sunitinib. Tumour heterogeinity is a matter of debate in mRCC. The aim of our study is to assess if pathological features and the expression of VEGF and VEGFRs polymorphisms in tumour, metastatic, and normal renal tissues could have a role in patients’ treatment and prognosis. Methods: We enrolled 123 patients treated at our institution. We collected histologic samples of tumour, metastatic, and normal renal tissue of 92 patients with mRCC treated with first-line sunitinib. For 21 patients, all three tissues were available. A pathological revision was conducted evaluating: granular cells percentage, grading, necrosis, regressive and sarcomatoid areas, and vascularization pattern. Histologic samples were tested for VEGF-A, VEGF-C and VEGFR-1,2,3 single nucleotide polymorphisms (SNPs). Polymorphisms were correlated with pathological features and PFS and OS. We then analysed concordance in SPNs expression among tissues. Results: VEGF A rs833061, VEGF A rs699947, VEGF A rs2010963, and VEGR3 rs6877011 were confirmed as significant SNPs in PFS. 19 out of 21 patients presented concordance among tissues polymorphisms expression (97%). The presence of a G allele in the rs6877011 seems to correlate with a higher percentage of granular cells. The presence of C allele in rs2010963 correlates with an alterated vascularazation. Conclusions: A preliminary analysis of our data shows the predictive and prognostic value of angiogenic polymorphisms and their concordance in tumoral, metastatic, and normal tissue. Furthermore, they are correlated with the percentage of granular cells and the vascular architecture, with possible predictive and prognostic significance. Further data will be presented at the meeting.

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