scholarly journals Systemic administration of bevacizumab prolongs survival in an in vivo model of platinum pre-treated ovarian cancer

2012 ◽  
Vol 3 (3) ◽  
pp. 530-534 ◽  
Author(s):  
DANIEL T. REIN ◽  
ANNE KATHRIN VOLKMER ◽  
JENS VOLKMER ◽  
INES M. BEYER ◽  
WOLFGANG JANNI ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Systemic Administration ◽  
In Vivo Model

scholarly journals Assessment of the immune landscapes of advanced ovarian cancer in an optimized in vivo model

2021 ◽  
Vol 11 (10) ◽  
Author(s):  
Simone Pisano ◽  
Stefania Lenna ◽  
Gareth D. Healey ◽  
Fereshteh Izardi ◽  
Lucille Meeks ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Advanced Ovarian Cancer ◽  
In Vivo Model

scholarly journals An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ying Zhang ◽  
Li Luo ◽  
Xueling Zheng ◽  
Tinghe Yu
Keyword(s):  
Ovarian Cancer ◽  
Survival Time ◽  
Biological Behavior ◽  
In Vivo Model ◽  
Ovarian Cancer Cells ◽  
Recipient Mouse ◽  
Cancer Model ◽  
Therapeutic Trials ◽  
Tumor Fragment

A nude mouse received subcutaneous injection of human ovarian cancer cells HO-8910PM to form a tumor, and then the tumor fragment was surgically transplanted to the ovary of a recipient mouse to establish an orthotopic cancer model. Tumors occurred in 100% of animals. A mouse displayed an ovarian mass, ascites, intraperitoneal spread, and lung metastasis at natural death. The mean survival time was34.1±17.2days, with median survival time of 28.5 days. The findings indicated that the present mouse model can reflect the biological behavior of advanced human ovarian cancers. This in vivo model can be used to explore therapeutic means against chemoresistance and metastasis, and an effective treatment would prolong the survival time.

scholarly journals Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Luiz Gustavo A Chuffa ◽  
Beatriz A Fioruci-Fontanelli ◽  
Leonardo O Mendes ◽  
Fábio R Ferreira Seiva ◽  
Marcelo Martinez ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Inflammatory Response ◽  
Signaling Pathways ◽  
In Vivo Model

EFFECTS OF SYSTEMIC ADMINISTRATION OF rIL-10 IN AN IN VIVO MODEL OF ALLOREACTIVITY

1994 ◽  
Vol 58 (8) ◽  
pp. 972-974 ◽  
Author(s):  
Anne Delvaux ◽  
Vincent Donckier ◽  
Catherine Bruyns ◽  
Sandrine Florquin ◽  
Catherine Gérard ◽  
...  
Keyword(s):  
Systemic Administration ◽  
In Vivo Model
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