scholarly journals Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells

2012 ◽  
Vol 5 (2) ◽  
pp. 588-592 ◽  
Author(s):  
KARAM KIM ◽  
SUNGKWAN AN ◽  
HWA JUN CHA ◽  
YEONG MIN CHOI ◽  
SUNG JIN CHOI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung

scholarly journals The Effect of Adenovirus-Mediated Gene Expression of FHIT in Small Cell Lung Cancer Cells

2011 ◽  
Vol 29 (10) ◽  
pp. 683-691 ◽  
Author(s):  
Roza Zandi ◽  
Kai Xu ◽  
Hans S. Poulsen ◽  
Jack A. Roth ◽  
Lin Ji
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung

scholarly journals Adenovirus-Mediated mda-7 Gene Expression Radiosensitizes Non-Small Cell Lung Cancer Cells via TP53-Independent Mechanisms

2002 ◽  
Vol 6 (5) ◽  
pp. 637-644 ◽  
Author(s):  
Shinichiro Kawabe ◽  
Takashi Nishikawa ◽  
Anupama Munshi ◽  
Jack A. Roth ◽  
Sunil Chada ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung

Changes in Gene Expression Associated with Stable Drug and Radiation Resistance in Small Cell Lung Cancer Cells are Similar to those Caused by a Single X-Ray Dose

2004 ◽  
Vol 161 (5) ◽  
pp. 495-503 ◽  
Author(s):  
Sheridan Henness ◽  
Mary W. Davey ◽  
Rozelle M. Harvie ◽  
Joanne Banyer ◽  
Valerie Wasinger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Radiation Resistance ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
X Ray

scholarly journals Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Jun Jiang ◽  
DengLiang Huang ◽  
Yuan Jiang ◽  
Jing Hou ◽  
MeiYuan Tian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Cellular Metabolism ◽  
Tca Cycle ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung

Lactate has been observed to fuel TCA cycle and is associated with cancer progression in human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate on lung cancer metabolism is rarely reported. In this study, disordered metabolism in non-small cell lung cancer was demonstrated by increased G6PD and SDHA protein levels via immunofluorescence, and up-regulated lactate dehydrogenase was found to be associated with poor prognosis. Then flow cytometry and Seahorse XFe analyzer were utilized to detect the effect of lactate on glycolysis and mitochondrial function in non-small cell lung cancer cells. The results show that in non-small cell lung cancer cells lactate attenuates glucose uptake and glycolysis while maintaining mitochondrial homeostasis as indicated by improved mitochondrial membrane potential. Further exploration found that mRNA levels of glycolytic enzymes (HK-1, PKM) and TCA cycle enzymes (SDHA, IDH3G) are respectively down-regulated and up-regulated by lactate, and increased histone lactylation was observed in promoters of HK-1 and IDH3G via chromatin immunoprecipitation assay. Taken together, the above results indicate that lactate modulates cellular metabolism at least in part through histone lactylation-mediated gene expression in non-small cell lung cancer.

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