Monte-Carlo simulations are used to calculate the primary yield of hydrogen peroxide (GH2O2) of the radiolysis of pure, deaerated liquid water as a function of linear energy transfer (LET) of the incident radiation over the range ~0.3100 keV µm1, at 25 and 300°C. The radiations include 1H+, 2H+, 4He2+, 7Li3+, and 12C6+ ions with energies from 0.17 MeV to 3.6 GeV. At 25°C, it is found that our GH2O2 values, calculated with protons of different initial energies, show a monotonic increase as a function of LET, in agreement with the commonly assumed expectation of an increase in molecular yields with increasing LET. Our calculated H2O2 yields at 300°C increase significantly faster with LET than do their corresponding 25°C values, showing that the temperature dependence of GH2O2 at higher LET is less than for low-LET radiation. We also report our results on the temporal variations of the H2O2 yields, in the interval ~1 × 1013 1 × 106 s, at 25 and 300°C and for the different types of radiation considered. Finally, we find that for incident ions of equal LET > 10 keV µm1, GH2O2 decreases as the ion velocity increases, from protons (or deuterons) to carbon ions. These differences produced in GH2O2 by changing the type of radiation are explained by the greater mean energy of secondary electrons from the higher velocity ions, which penetrate to a greater average distance from the actual particle track, with a corresponding decrease in molecular yields. Our calculated GH2O2 values compare generally well with the experimental data available from the literature and are also in good accord with the predictions of deterministic diffusion-kinetic model calculations reported earlier.Key words: liquid water, radiolysis, primary yields, hydrogen peroxide (H2O2), linear energy transfer (LET), accelerated protons and heavy ions, temperature, Monte-Carlo simulations.
Development of a novel enzyme-targeting radiosensitizer (KORTUC) containing hydrogen peroxide for intratumoral injection for patients with low linear energy transfer-radioresistant neoplasms