scholarly journals PGAM1 knockdown is associated with busulfan‑induced hypospermatogenesis and spermatogenic cell apoptosis

2019 ◽  
Author(s):  
Yuanshu Zhao ◽  
Shoubo Zhang
Keyword(s):  
Cell Apoptosis ◽  
Spermatogenic Cell

scholarly journals Mechanism of Heshouwuyin inhibiting the Cyt c/Apaf-1/Caspase-9/Caspase-3 pathway in spermatogenic cell apoptosis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hongjie Wang ◽  
Juan Zhu ◽  
Liping Jiang ◽  
Boying Shan ◽  
Peihan Xiao ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Caspase 3 ◽  
Spermatogenic Cell ◽  
Caspase 9 ◽  
Cyt C

Fas-Fas ligand system as a possible mediator of spermatogenic cell apoptosis in human maturation-arrested testes

Human Cell ◽  
2002 ◽  
Vol 15 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Jiro Eguchi ◽  
Takehiko Koji ◽  
Koichiro Nomata ◽  
Akira Yoshii ◽  
Masashi Shin ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Fas Ligand ◽  
Spermatogenic Cell ◽  
Ligand System

scholarly journals Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Yuan Tian ◽  
Yuehai Xiao ◽  
Bolin Wang ◽  
Chao Sun ◽  
Kaifa Tang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Protein Kinase ◽  
Cell Apoptosis ◽  
Sperm Count ◽  
Mitogen Activated Protein Kinase ◽  
Spermatogenic Cell ◽  
Erk Signaling ◽  
Male Rat ◽  
Coal Burning

Although fluoride has been widely used in toothpaste, mouthwash, and drinking water to prevent dental caries, the excessive intake of fluoride can cause fluorosis which is associated with dental, skeletal, and soft tissue fluorosis. Recent evidences have drawn the attention to its adverse effects on male reproductive system that include spermatogenesis defect, sperm count loss, and sperm maturation impairment. Fluoride induces oxidative stress through the activation of mitogen activated protein kinase (MAPK) cascade which can lead to cell apoptosis. Vitamin E (VE) and lycopene are two common antioxidants, being protective to reactive oxygen species (ROS)-induced toxic effects. However, whether and how these two antioxidants prevent fluoride-induced spermatogenic cell apoptosis are largely unknown. In the present study, a male rat model for coal burning fluorosis was established and the histological lesions and spermatogenic cell apoptosis in rat testes were observed. The decreased expression of clusterin, a heterodimeric glycoprotein reported to regulate spermatogenic cell apoptosis, was detected in fluoride-treated rat testes. Interestingly, the co-administration with VE or lycopene reduced fluorosis-mediated testicular toxicity and rescued clusterin expression. Further, fluoride caused the enhanced Jun N-terminal kinase (JNK, c-Jun) and extracellular signal-regulated protein kinase (ERK) phosphorylation, which was reduced by VE or lycopene. Thus, VE and lycopene prevent coal burning fluorosis-induced spermatogenic cell apoptosis through the suppression of oxidative stress-mediated JNK and ERK signaling pathway, which could be an alternative therapeutic strategy for the treatment of fluorosis.

scholarly journals Seminal plasma miR-210-3p induces spermatogenic cell apoptosis by activating caspase-3 in patients with varicocele

2020 ◽  
Vol 22 (5) ◽  
pp. 513
Author(s):  
Ye-Gang Chen ◽  
Xiao-Qiang Liu ◽  
Ya-Wei Xu ◽  
Ning-Jing Ou ◽  
Yu-Xuan Song ◽  
...  
Keyword(s):  
Seminal Plasma ◽  
Cell Apoptosis ◽  
Caspase 3 ◽  
Spermatogenic Cell

Involvement of 16kDa Prolactin in Spermatogenic Cell Apoptosis in Mice with Experimental Cryptorchidism

2011 ◽  
pp. P2-357-P2-357
Author(s):  
Yu Yanagisawa ◽  
Masafumi Shimada ◽  
Kenichi Sobue ◽  
Michiyo Ishida ◽  
Toshio Harigaya
Keyword(s):  
Cell Apoptosis ◽  
Spermatogenic Cell

Prolactin induced spermatogenic cell apoptosis presents differently at various hormone environments

2007 ◽  
Vol 88 ◽  
pp. S384-S385
Author(s):  
W.J. Huang ◽  
P.S. Wang ◽  
J.-Y. Yeh ◽  
L.S. Chang
Keyword(s):  
Cell Apoptosis ◽  
Spermatogenic Cell

Butylbenzyl phthalate induces spermatogenic cell apoptosis in prepubertal rats

2016 ◽  
Vol 48 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Mohammad Shah Alam ◽  
Masamichi Kurohmaru
Keyword(s):  
Cell Apoptosis ◽  
Spermatogenic Cell ◽  
Prepubertal Rats

Exposure to 3-methyl-4-nitrophenol affects testicular morphology and induces spermatogenic cell apoptosis in immature male rats

2011 ◽  
Vol 91 (2) ◽  
pp. 261-268 ◽  
Author(s):  
Zhuo Yue ◽  
Ruiping She ◽  
Huihui Bao ◽  
Wengui Li ◽  
Decheng Wang ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Spermatogenic Cell ◽  
Male Rats ◽  
Immature Male ◽  
Testicular Morphology
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