scholarly journals Potential role of microRNA‑223‑3p in the tumorigenesis of hepatocellular carcinoma: A comprehensive study based on data mining and bioinformatics

2017 ◽  
Author(s):  
Rui Zhang ◽  
Li‑Jie Zhang ◽  
Mei‑Ling Yang ◽  
Lan‑Shan Huang ◽  
Gang Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Data Mining ◽  
Potential Role ◽  
Comprehensive Study

scholarly journals Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 C>G) in hepatocellular carcinoma risk

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1110-1111 ◽  
Author(s):  
Emeric Limagne ◽  
Vanessa Cottet ◽  
Alexia Karen Cotte ◽  
Samia Hamza ◽  
Patrick Hillon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Potential Role ◽  
The Impact ◽  
Carcinoma Risk

Role of BCYRN1 in hepatocellular carcinoma pathogenesis by lncRNA–miRNA–mRNA network analysis and its diagnostic and prognostic value

Epigenomics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1209-1231 ◽  
Author(s):  
Xin-Liang Ming ◽  
Yan-Lin Feng ◽  
Ding-Dong He ◽  
Chang-Liang Luo ◽  
Jia-Ling Rong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Data Mining ◽  
Microarray Data ◽  
Prognostic Value ◽  
Prognostic Biomarker ◽  
Tumor Node Metastasis ◽  
Comprehensive Strategy ◽  
Node Metastasis ◽  
Diagnostic And Prognostic Value

Aim: This study aimed to excavate the roles of BCYRN1 in hepatocellular carcinoma (HCC). Methods: A comprehensive strategy of microarray data mining, computational biology and experimental verification were adopted to assess the clinical significance of BCYRN1 and identify related pathways. Results: BCYRN1 was upregulated in HCC and its expression was positively associated with both tumor, node, metastasis and worse survival rate in patients with HCC. Through combing plasma BCYRN1 with alpha fetoprotein, the diagnosis of HCC was remarkably improved. BCYRN1 may regulate some cancer-related pathways to promote HCC initiation via an lncRNA–miRNA–mRNA network. Conclusion: Our results propose BCYRN1 as a potential diagnostic and prognostic biomarker and offer a novel perspective to explore the etiopathogenesis of HCC.

Potential role of lncRNA-TSIX, miR-548-a-3p, and SOGA1 mRNA in the diagnosis of hepatocellular carcinoma

2019 ◽  
Vol 46 (4) ◽  
pp. 4581-4590 ◽  
Author(s):  
Alaa Habieb ◽  
Marwa Matboli ◽  
Hanaa El-Tayeb ◽  
Farid El-Asmar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Potential Role

The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma

Gene ◽  
2016 ◽  
Vol 575 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Khalda Said Amr ◽  
Wafaa M. Ezzat ◽  
Yasser A. Elhosary ◽  
Abdelfattah E. Hegazy ◽  
Hoda H. Fahim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Diagnosis ◽  
Potential Role

Potential role of miR-214 in β-catenin gene expression within hepatocellular carcinoma

2020 ◽  
Vol 47 (10) ◽  
pp. 7429-7437
Author(s):  
Hamzeh Karimkhanloo ◽  
Samira Mohammadi-Yeganeh ◽  
Razie Hadavi ◽  
Ameneh Koochaki ◽  
Mahdi Paryan
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Potential Role

scholarly journals An Evidence-Based Multidisciplinary Approach to the Management of Hepatocellular Carcinoma (HCC): The Alberta HCC Algorithm

2010 ◽  
Vol 24 (11) ◽  
pp. 643-650 ◽  
Author(s):  
Kelly W Burak ◽  
Norman M Kneteman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Function ◽  
Potential Role ◽  
Staging System ◽  
Evidence Based ◽  
Transarterial Radioembolization ◽  
Bclc Staging ◽  
Tumour Characteristics

Hepatocellular carcinoma (HCC) is one of only a few malignancies with an increasing incidence in North America. Because the vast majority of HCCs occur in the setting of a cirrhotic liver, management of this malignancy is best performed in a multidisciplinary group that recognizes the importance of liver function, as well as patient and tumour characteristics. The Barcelona Clinic Liver Cancer (BCLC) staging system is preferred for HCC because it incorporates the tumour characteristics (ie, tumour-node-metastasis stage), the patient’s performance status and liver function according to the Child-Turcotte-Pugh classification, and then links the BCLC stage to recommended therapeutic interventions. However, the BCLC algorithm does not recognize the potential role of radiofrequency ablation for very early stage HCC, the expanding role of liver transplantation in the management of HCC, the role of transarterial chemoembolization in single large tumours, the potential role of transarterial radioembolization with90Yttrium and the limited evidence for using sorafenib in Child-Turcotte-Pugh class B cirrhotic patients. The current review article presents an evidence-based approach to the multidisciplinary management of HCC along with a new algorithm for the management of HCC that incorporates the BCLC staging system and the authors’ local selection criteria for resection, ablative techniques, liver transplantation, transarterial chemoembolization, transarterial radioembolization and sorafenib in Alberta.

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