scholarly journals Gene expression profiles and protein‑protein interaction networks during tongue carcinogenesis in the tumor microenvironment

2017 ◽  
Author(s):  
Wei Sun ◽  
Zeting Qiu ◽  
Wenqi Huang ◽  
Minghui Cao
Keyword(s):  
Gene Expression ◽  
Tumor Microenvironment ◽  
Protein Interaction ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Protein Interaction Networks ◽  
Interaction Networks ◽  
Protein Protein Interaction ◽  
Protein Protein Interaction Networks

scholarly journals Genome-Wide Characterization and Expression Analysis of bZIP Gene Family Under Abiotic Stress in Glycyrrhiza uralensis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuxuan Han ◽  
Zhuoni Hou ◽  
Qiuling He ◽  
Xuemin Zhang ◽  
Kaijing Yan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Abiotic Stress ◽  
Gene Family ◽  
Protein Interaction ◽  
Protein Interaction Networks ◽  
Interaction Networks ◽  
Glycyrrhiza Uralensis ◽  
Protein Protein Interaction ◽  
Genome Wide ◽  
Protein Protein Interaction Networks

bZIP gene family is one of the largest transcription factor families. It plays an important role in plant growth, metabolic, and environmental response. However, complete genome-wide investigation of bZIP gene family in Glycyrrhiza uralensis remains unexplained. In this study, 66 putative bZIP genes in the genome of G. uralensis were identified. And their evolutionary classification, physicochemical properties, conserved domain, functional differentiation, and the expression level under different stress conditions were further analyzed. All the members were clustered into 13 subfamilies (A–K, M, and S). A total of 10 conserved motifs were found in GubZIP proteins. Members from the same subfamily shared highly similar gene structures and conserved domains. Tandem duplication events acted as a major driving force for the evolution of bZIP gene family in G. uralensis. Cis-acting elements and protein–protein interaction networks showed that GubZIPs in one subfamily are involved in multiple functions, while some GubZIPs from different subfamilies may share the same functional category. The miRNA network targeting GubZIPs showed that the regulation at the transcriptional level may affect protein–protein interaction networks. We suspected that domain-mediated interactions may categorize a protein family into subfamilies in G. uralensis. Furthermore, the tissue-specific gene expression patterns of GubZIPs were analyzed using the public RNA-seq data. Moreover, gene expression level of 66 bZIP family members under abiotic stress treatments was quantified by using qRT-PCR. The results of this study may serve as potential candidates for functional characterization in the future.

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