scholarly journals Downregulation of AQP2 in the anterior vaginal wall is associated with the pathogenesis of female stress urinary incontinence

2017 ◽  
Vol 16 (3) ◽  
pp. 3503-3509 ◽  
Author(s):  
Zujuan Zhang ◽  
Pan Xu ◽  
Zhenwei Xie ◽  
Fengxian Shen ◽  
Ning Chen ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Female Stress Urinary Incontinence

scholarly journals Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249977
Author(s):  
Xiaoyan Sun ◽  
Huimin Zhu ◽  
Wenjuan Li ◽  
Li Zhao ◽  
Wenhua Li ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Extracellular Vesicles ◽  
Underlying Mechanism ◽  
Inhibitory Effect ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Female Stress Urinary Incontinence ◽  
Migration Capacity ◽  
Vaginal Fibroblasts

Stress urinary incontinence (SUI) is a common condition in women and associated with extra-cellular matrix (ECM) reconstruction, which is mainly regulated by fibroblasts. However, the underlying mechanism remains obscure. Small extracellular vesicles (sEVs) play fundamental biological roles in various cellular functions. Some studies suggested that the sEVs were involved in the metabolism of ECM and the function of fibroblasts. The purpose of our study was to investigate the effect of sEVs secreted by vaginal fibroblasts on the pathogenesis of SUI. We showed that the fibroblasts of female anterior vaginal wall secreted sEVs. Moreover, fibroblasts of females with SUI had significantly elevated secretion of sEVs. The collagen contents, proliferation and migration capacity of fibroblasts were decreased when fibroblasts were co-cultured with fibroblasts-derived sEVs (fibroblast-sEVs) from SUI patients. Proteomic analysis revealed that fibroblast-sEVs contained various differentially expressed proteins including TIMP2, TGF-β and ABCC4, which were involved in signaling pathways of fibroblasts regulation. Therefore, we suggested that fibroblast-sEVs contributed to the pathogenesis of SUI through various proteins including TIMP2, TGF-β and ABCC4.

scholarly journals Outcome of Treatment of Anterior Vaginal Wall Prolapse and Stress Urinary Incontinence with Transobturator Tension-Free Vaginal Mesh (Prolift) and Concomitant Tension-Free Vaginal Tape-Obturator

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Ashraf Abou-Elela ◽  
Essam Salah ◽  
Haitham Torky ◽  
Sameh Azazy
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Vaginal Mesh ◽  
Anterior Vaginal Wall Prolapse ◽  
Tension Free ◽  
Tension Free Vaginal Tape ◽  
Urodynamic Assessment ◽  
Vaginal Tape Obturator

Objective. It is to assess the feasibility, effectiveness, and safety of transobturator tension-free vaginal mesh (Prolift) and concomitant tension-free vaginal tape-obturator (TVT-O) system as a treatment of female anterior vaginal wall prolapse associated with stress urinary incontinence (SUI).Patients and Methods. Between December 2006 and July 2007, 20 patients with anterior genital prolapse and voiding dysfunction were treated with the transobturator tension-free vaginal mesh (Prolift) and concomitant tension-free vaginal tape-obturator (TVT-O). Sixteen patients had stress urinary incontinence and 4 patients were considered at risk for development of de novo stress incontinence after the prolapse is repaired. All patients underwent a complete urodynamic assessment. All the patients underwent pelvic examination 4–6 weeks after the operation, and anatomical and functional outcomes were recorded.Results. Twenty cystocoeles were repaired: 6 grade II, 12 grade III, and 2 grade IV. There were no vessel or bladder injuries. Eighteen patients had optimal anatomic results and 2 patients had persistent asymptomatic stage I prolapse.Conclusion. These preliminary results suggest that Prolift system offers a safe and effective treatment for female anterior vaginal wall prolapse. However, a long-term followup is necessary in order to support the good result maintenance.

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