scholarly journals Synergistic protective effect of FTY720 and vitamin E against simulated cerebral ischemia in vitro

2017 ◽  
Vol 16 (1) ◽  
pp. 396-402 ◽  
Author(s):  
Xin Pang ◽  
Xuening Hou
Keyword(s):  
Vitamin E ◽  
Cerebral Ischemia ◽  
Protective Effect

Protective Effect of Vitamin E on Immune Triggered, Granulocyte Mediated Endothelial Injury

1984 ◽  
Vol 51 (01) ◽  
pp. 089-092 ◽  
Author(s):  
M A Boogaerts ◽  
J Van de Broeck ◽  
H Deckmyn ◽  
C Roelant ◽  
J Vermylen ◽  
...  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Umbilical Vein ◽  
Endothelial Damage ◽  
Endothelial Injury ◽  
Mediated Effects ◽  
Anti Oxidant ◽  
Endothelial Cell Cultures ◽  
Vitro Model

SummaryThe effect of alfa-tocopherol on the cell-cell interactions at the vessel wall were studied, using an in vitro model of human umbilical vein endothelial cell cultures (HUEC). Immune triggered granulocytes (PMN) will adhere to and damage HUEC and platelets enhance this PMN mediated endothelial injury. When HUEC are cultured in the presence of vitamin E, 51Cr-leakage induced by complement stimulated PMN is significantly decreased and the enhanced cytotoxicity by platelets is completely abolished (p <0.001).The inhibition of PMN induced endothelial injury is directly correlated to a diminished adherence of PMN to vitamin E- cultured HUEC (p <0.001), which may be mediated by an increase of both basal and stimulated endogenous prostacyclin (PGI2) from alfa-tocopherol-treated HUEC (p <0.025). The vitamin E-effect is abolished by incubation of HUEC with the irreversible cyclo-oxygenase inhibitor, acetylsalicylic acid, but the addition of exogenous PGI2 could not reproduce the vitamin E-mediated effects.We conclude that vitamin E exerts a protective effect on immune triggered endothelial damage, partly by increasing the endogenous anti-oxidant potential, partly by modulating intrinsic endothelial prostaglandin production. The failure to reproduce vitamin E-protection by exogenously added PGI2 may suggest additional, not yet elucidated vitamin E-effects on endothelial metabolism.

Protective effect of vitamin E on lymphocyte growth capacity during incubation in vitro

1995 ◽  
Vol 82 (2-3) ◽  
pp. 129-148 ◽  
Author(s):  
Ke-Yin Tu ◽  
Randall Matthews ◽  
Kathleen S. Matthews
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Growth Capacity ◽  
Lymphocyte Growth

Hepatotoxic effect of ochratoxin A and citrinin, alone and in combination, and protective effect of vitamin E: In vitro study in HepG2 cell

2015 ◽  
Vol 83 ◽  
pp. 151-163 ◽  
Author(s):  
Loganathan Gayathri ◽  
Rajakumar Dhivya ◽  
Dharumadurai Dhanasekaran ◽  
Vaiyapuri S. Periasamy ◽  
Ali A. Alshatwi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Ochratoxin A ◽  
Hepg2 Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
Hepatotoxic Effect

Sensitivity of ATPase-ADPase activities from synaptic plasma membranes of rat forebrain to lipid peroxidation in vitro and the protective effect of vitamin E

1996 ◽  
Vol 21 (3) ◽  
pp. 299-304 ◽  
Author(s):  
Marion Vietta ◽  
Silvana S. Frassetto ◽  
Ana M. O. Battastini ◽  
Adriane Bello-Klein ◽  
Cleci Moreira ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Protective Effect ◽  
Plasma Membranes ◽  
Synaptic Plasma Membranes ◽  
Rat Forebrain

UVA-induced immune suppression in human skin: protective effect of vitamin E in human epidermal cells in vitro

1996 ◽  
Vol 134 (1) ◽  
pp. 77-84 ◽  
Author(s):  
P. CLEMENT-LACROIX ◽  
L. MICHEL ◽  
A. MOYSAN ◽  
P. MORLIERE ◽  
L. DUBERTRET
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Human Skin ◽  
Immune Suppression ◽  
Epidermal Cells ◽  
Human Epidermal Cells

The protective effect of vitamin E on cerebral ischemia

1984 ◽  
Vol 22 (5) ◽  
pp. 449-454 ◽  
Author(s):  
Shunichi Fujimoto ◽  
Kazuo Mizoi ◽  
Takashi Yoshimoto ◽  
Jiro Suzuki
Keyword(s):  
Vitamin E ◽  
Cerebral Ischemia ◽  
Protective Effect

UVA-induced immune suppression in human skin: protective effect of vitamin E in human epidermal cells in vitro

1996 ◽  
Vol 134 (1) ◽  
pp. 77-84 ◽  
Author(s):  
P. CLEMENT-LACROIX ◽  
L. MICHEL ◽  
A. MOYSAN ◽  
P. MORLIERE ◽  
L. DUBERTRET
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Human Skin ◽  
Immune Suppression ◽  
Epidermal Cells ◽  
Human Epidermal Cells
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