scholarly journals Resistance of mitochondrial DNA-depleted cells against oxidized low-density lipoprotein-induced macrophage pyroptosis

2016 ◽  
Vol 13 (5) ◽  
pp. 4393-4399 ◽  
Author(s):  
HAI YAN ◽  
YUNYUN LI ◽  
XUE PENG ◽  
DAKE HUANG ◽  
LI GUI ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

LOX-1, oxidant stress, mtDNA damage, autophagy, and immune response in atherosclerosis

2014 ◽  
Vol 92 (7) ◽  
pp. 524-530 ◽  
Author(s):  
Zufeng Ding ◽  
Shijie Liu ◽  
Xianwei Wang ◽  
Yao Dai ◽  
Magomed Khaidakov ◽  
...  
Keyword(s):  
Immune Response ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Oxidant Stress ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Mitochondrial Dna Damage ◽  
Monocyte Migration

As a major receptor for oxidized low density lipoprotein (ox-LDL), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in many pathophysiological events, including endothelial cell dysfunction and smooth muscle cell growth, as well as monocyte migration and transformation into foam cells, which are present in atherosclerosis and myocardial ischemia. Excessive production of reactive oxygen species (ROS) increases LOX-1 expression, induces mitochondrial DNA damage, and activates autophagy. Damaged mitochondrial DNA that escapes from autophagy induces an inflammatory response. This paper reviews the potential link between LOX-1, mitochondrial DNA damage, autophagy, and immune response in atherosclerosis.

scholarly journals Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

1994 ◽  
Vol 35 (4) ◽  
pp. 669-677
Author(s):  
H.N. Hodis ◽  
D.M. Kramsch ◽  
P. Avogaro ◽  
G. Bittolo-Bon ◽  
G. Cazzolato ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Oxidized low density lipoprotein inhibits macrophage apoptosis through activation of the PI 3-kinase/PKB pathway

2001 ◽  
Vol 42 (9) ◽  
pp. 1483-1491 ◽  
Author(s):  
Rajinder S. Hundal ◽  
Baljinder S. Salh ◽  
John W. Schrader ◽  
Antonio Gómez-Muñoz ◽  
Vincent Duronio ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Macrophage Apoptosis

scholarly journals CD36 is a receptor for oxidized low density lipoprotein

1993 ◽  
Vol 268 (16) ◽  
pp. 11811-11816 ◽  
Author(s):  
G. Endemann ◽  
L.W. Stanton ◽  
K.S. Madden ◽  
C.M. Bryant ◽  
R.T. White ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein
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