scholarly journals Effects and mechanism of downregulation of survivin expression by RNA interference on proliferation and apoptosis of lung cancer cells

2012 ◽  
Vol 5 (4) ◽  
pp. 917-922 ◽  
Author(s):  
XIANG-QI CHEN ◽  
SHENG YANG ◽  
ZHI-YING LI ◽  
HUI-SHAN LU ◽  
MING-QIANG KANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Rna Interference ◽  
Cancer Cells ◽  
Survivin Expression ◽  
Lung Cancer Cells ◽  
Proliferation And Apoptosis

scholarly journals Protective Effect of Caffeic Acid on Paclitaxel Induced Anti-Proliferation and Apoptosis of Lung Cancer Cells Involves NF-κB Pathway

2012 ◽  
Vol 13 (5) ◽  
pp. 6236-6245 ◽  
Author(s):  
Chien-Liang Lin ◽  
Ruei-Feng Chen ◽  
Jeff Yi-Fu Chen ◽  
Ying-Chieh Chu ◽  
Hui-Min Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protective Effect ◽  
Cancer Cells ◽  
Caffeic Acid ◽  
Lung Cancer Cells ◽  
Proliferation And Apoptosis

scholarly journals Survivin expression modulates the sensitivity of A549 lung cancer cells resistance to vincristine

2018 ◽  
Author(s):  
Chengwei Zhou ◽  
Yonggang Zhu ◽  
Bin Lu ◽  
Weijun Zhao ◽  
Xiaodong Zhao
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Survivin Expression ◽  
Lung Cancer Cells ◽  
A549 Lung

scholarly journals Inhibition of ITCH Suppresses Proliferation and Induces Apoptosis of Lung Cancer Cells

2018 ◽  
Vol 48 (4) ◽  
pp. 1703-1709 ◽  
Author(s):  
Peng-Fei Li ◽  
Qi-Gang Zhang
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Cancer Proliferation ◽  
Flow Cytometric ◽  
Tumor Tissues ◽  
Proliferation And Apoptosis ◽  
Underlying Mechanisms ◽  
Cancer Tissues ◽  
Proliferation And Invasion

Background/Aims: The E3 ubiquitin ligase ITCH plays an important role in invasive and metastatic cancers. However, the role of ITCH in the progression of lung cancer has not been fully described. Methods: Real-time PCR was used to detect the expression of ITCH mRNA in the tumor tissues and paracarcinoma tissues from 32 patients with lung cancer. SiRNA was used to inhibit the expression of ITCH in two lung cancer cell lines, H1975 and Calu3 and the cell proliferation and apoptosis were measured by MTT and flow cytometric assay. In addition, to further investigate whether ITCH affected the apoptosis of cancer cells and its underlying mechanisms, the expression of important markers of apoptosis and invasion in lung cancer cells were detected by Western blot. Results: The study showed significant increments in the expression of ITCH in lung cancer tissues (p< 0.001). ITCH siRNA effectively inhibited the proliferation and invasion of the lung cancer cells and promoted cell apoptosis. Molecular analysis further showed significant reductions in the expression of Bcl2, MMP2, MMP9 and β-catenin and an increase in the expression of Bax and E-cadherin in the lung cancer cells with ITCH deficiency. Conclusions: Inhibition of ITCH might suppress lung cancer proliferation and invasion via regulation of MMPs, EMT and Bcl2/Bax signaling pathway.

scholarly journals PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells

2014 ◽  
Vol 12 (1) ◽  
pp. 258 ◽  
Author(s):  
Chen Zhang ◽  
Yuanzhuo Chen ◽  
Mingsong Wang ◽  
Xianzhen Chen ◽  
Yongxin Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Rna Interference ◽  
Cancer Cells ◽  
Lung Cancer Cells

scholarly journals Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells

2020 ◽  
Vol 20 (2) ◽  
pp. 1256-1262
Author(s):  
Yan Huang ◽  
Ting Bao ◽  
Zhenzhen Li ◽  
Guiyi Ji ◽  
Li Zhang
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Proliferation And Apoptosis
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