scholarly journals Identification of differentially expressed microRNAs and the possible role of miRNA-126* in Sprague-Dawley rats during fetal lung development

2012 ◽  
Vol 7 (1) ◽  
pp. 65-72 ◽  
Author(s):  
YANG YANG ◽  
XIAO-DAN PU ◽  
KAN QING ◽  
XI-RONG GUO ◽  
XIAO-YU ZHOU ◽  
...  
Keyword(s):  
Lung Development ◽  
Fetal Lung ◽  
Differentially Expressed ◽  
Sprague Dawley ◽  
Fetal Lung Development ◽  
Sprague Dawley Rats

The role of JAK-STAT3 signaling pathway during fetal lung development

2008 ◽  
Vol 84 ◽  
pp. S79-S80 ◽  
Author(s):  
Cristina Nogueira-Silva ◽  
Susana Nunes ◽  
Rute S. Moura ◽  
Jorge Correia-Pinto
Keyword(s):  
Signaling Pathway ◽  
Lung Development ◽  
Fetal Lung ◽  
Stat3 Signaling ◽  
Fetal Lung Development ◽  
Stat3 Signaling Pathway

scholarly journals Role of GABA Receptors in Fetal Lung Development in Rats

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e14171 ◽  
Author(s):  
Narendranath Reddy Chintagari ◽  
Nili Jin ◽  
Li Gao ◽  
Yang Wang ◽  
Dong Xi ◽  
...  
Keyword(s):  
Gaba Receptors ◽  
Lung Development ◽  
Fetal Lung ◽  
Fetal Lung Development

The role of glycoprotein 130 (gp130) family of cytokines on fetal lung development mechanisms

2008 ◽  
Vol 84 ◽  
pp. S80-S81
Author(s):  
Cristina Nogueira-Silva ◽  
Emanuel Dias ◽  
Rute S. Moura ◽  
Jorge Correia-Pinto
Keyword(s):  
Lung Development ◽  
Fetal Lung ◽  
Fetal Lung Development

scholarly journals Mild DOCA-salt hypertension: sympathetic system and role of renal nerves

2011 ◽  
Vol 300 (5) ◽  
pp. H1781-H1787 ◽  
Author(s):  
Sachin S. Kandlikar ◽  
Gregory D. Fink
Keyword(s):  
Control Period ◽  
Whole Body ◽  
Renal Nerves ◽  
Experimental Hypertension ◽  
Sympathetic Activation ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Salt Hypertension ◽  
Hypertension Development

Excess sympathetic nervous system activity (SNA) is linked to human essential and experimental hypertension. To test whether sympathetic activation is associated with a model of deoxycorticosterone acetate (DOCA)-salt hypertension featuring two kidneys and a moderate elevation of blood pressure, we measured whole body norepinephrine (NE) spillover as an index of global SNA. Studies were conducted in chronically catheterized male Sprague-Dawley rats drinking water containing 1% NaCl and 0.2% KCl. After a 7-day surgical recovery and a 3-day control period, a DOCA pellet (50 mg/kg) was implanted subcutaneously in one group of rats (DOCA), while the other group underwent sham implantation (Sham). NE spillover was measured on control day 2 and days 7 and 14 after DOCA administration or sham implantation. During the control period, mean arterial pressure (MAP) was similar in Sham and DOCA rats. MAP was significantly increased in the DOCA group compared with the Sham group after DOCA administration ( day 14: Sham = 109 ± 5.3, DOCA = 128 ± 3.6 mmHg). However, plasma NE concentration, clearance, and spillover were not different in the two groups at any time. To determine whether selective sympathetic activation to the kidneys contributes to hypertension development, additional studies were performed in renal denervated (RDX) and sham-denervated (Sham-DX) rats. MAP, measured by radiotelemetry, was similar in both groups during the control and DOCA treatment periods. In conclusion, global SNA is not increased during the development of mild DOCA-salt hypertension, and fully intact renal nerves are not essential for hypertension development in this model.

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