scholarly journals Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro

2012 ◽  
Vol 6 (5) ◽  
pp. 1018-1022 ◽  
Author(s):  
XIAO-MAN XU ◽  
YI ZHANG ◽  
DAN QU ◽  
XUE-WEI FENG ◽  
YU CHEN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Human Lung Cancer Cells ◽  
Matrix Metallopeptidase ◽  
Matrix Metallopeptidase 9

scholarly journals Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro

2015 ◽  
Vol 34 (4) ◽  
pp. 1853-1874 ◽  
Author(s):  
I-TSANG CHIANG ◽  
WEI-SHU WANG ◽  
HSIN-CHUNG LIU ◽  
SU-TSO YANG ◽  
NOU-YING TANG ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Cell Cycle ◽  
Dna Damage ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Damage Cell ◽  
Human Lung Cancer Cells

scholarly journals Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs

2020 ◽  
Vol 21 (9) ◽  
pp. 3080 ◽  
Author(s):  
Kun-Hung Shen ◽  
Jui-Hsiang Hung ◽  
Yi-Ching Liao ◽  
Shu-Ting Tsai ◽  
Ming-Jiuan Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Matrix Metalloproteinase ◽  
Cell Invasion ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Mesenchymal Transition ◽  
E Cadherin

Sinomenine is an alkaloid derived from Sinomenium acutum. Recent studies have found that sinomenine can inhibit various cancers by inhibiting the proliferation, migration and invasion of tumors and inducing apoptosis. This study aims to investigate the effect and mechanism of sinomenine on inhibiting the migration and invasion of human lung adenocarcinoma cells in vitro. The results demonstrate that viabilities of A549 and H1299 cells were inhibited by sinomenine in a dose-dependent manner. When treated with sub-toxic doses of sinomenine, cell migration and invasion are markedly suppressed. Sinomenine decreases the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9, and the extracellular inducer of matrix metalloproteinase (EMMPRIN/CD147), but elevates the expression of reversion-inducing cysteine-rich proteins with kazal motifs (RECK) and the tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2. In addition, sinomenine significantly increases the expression of the epithelial marker E-cadherin but concomitantly decreases the expression of the mesenchymal marker vimentin, suggesting that it suppresses epithelial–mesenchymal transition (EMT). Moreover, sinomenine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. The downregulation of miR-21 decreases cell invasion, while the upregulation of miR-21 increases cell invasion. Furthermore, the downregulation of miR-21 stimulates the expression of RECK, TIMP-1/-2, and E-cadherin, but reduces the expression of MMP-2/-9, EMMPRIN/CD147, and vimentin. Taken together, the results reveal that the inhibition of A549 cell invasion by sinomenine may, at least in part, be through the downregulating expression of MMPs and miR-21. These findings demonstrate an attractive therapeutic potential for sinomenine in lung cancer anti-metastatic therapy.

scholarly journals Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro

2016 ◽  
Vol 37 (7) ◽  
pp. 919-929 ◽  
Author(s):  
Guo-dong Yao ◽  
Jing Yang ◽  
Qiang Li ◽  
Ye Zhang ◽  
Min Qi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Pseudolaric Acid B ◽  
Human Lung Cancer Cells
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