scholarly journals RNA interference targeting NRP-1 inhibits human glioma cell proliferation and enhances cell apoptosis

2011 ◽  
Author(s):  
Yanyan Huang
Keyword(s):  
Cell Proliferation ◽  
Rna Interference ◽  
Cell Apoptosis ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Proliferation

scholarly journals Long Intergenic Noncoding RNA 00152 Promotes Glioma Cell Proliferation and Invasion by Interacting with MiR-16

2018 ◽  
Vol 46 (3) ◽  
pp. 1055-1064 ◽  
Author(s):  
Xin Chen ◽  
Deheng Li ◽  
Yang Gao ◽  
Wei Tang ◽  
Lao IW ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Lines ◽  
Glioma Cell Proliferation ◽  
Proliferation And Invasion

Background/Aims: Long noncoding RNAs (lncRNAs) are a novel class of protein-noncoding transcripts that are aberrantly expressed in multiple diseases including cancers. LINC00152 has been identified as an oncogene involved in many kinds of cancer; however, its expression pattern and function in human glioma remain unclear. Methods: Quantitative real-time polymerase chain reaction was carried out to measure LINC00152 expression in human glioma cell lines and tissues. CCK-8 and EdU assays were performed to assess cell proliferation, and scratch assays and Transwell assays were used to assess cell migration and invasion, respectively. Luciferase reporter assays were carried out to determine the interaction between miR-16 and LINC00152. In vivo experiments were conducted to assess tumor formation. Results: LINC00152 was found to be significantly upregulated in human glioma cell lines and clinical samples. Knockdown of LINC00152 suppressed glioma cell proliferation, migration, and invasion in vitro. In vivo assays in nude mice confirmed that LINC00152 knockdown inhibits tumor growth. Furthermore, mechanistic investigation showed that LINC00152 binds to miR-16 in a sequence-specific manner and suppresses its expression. miR-16 inhibition strongly attenuated LINC00152 knockdown–mediated suppressive effects on proliferation, migration, and invasion. Moreover, LINC00152 induced BMI1 expression by sponging miR-16; this effect further promoted glioma cell proliferation and invasion. Conclusion: We regard LINC00152 as an oncogenic lncRNA promoting glioma cell proliferation and invasion and as a potential target for human glioma treatment.

scholarly journals Acyl-CoA Synthetase VL3 Knockdown Inhibits Human Glioma Cell Proliferation and Tumorigenicity

2009 ◽  
Vol 69 (24) ◽  
pp. 9175-9182 ◽  
Author(s):  
Zhengtong Pei ◽  
Peng Sun ◽  
Ping Huang ◽  
Bachchu Lal ◽  
John Laterra ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Proliferation

MicroRNA-370-3p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting β-catenin

2016 ◽  
Vol 1644 ◽  
pp. 53-61 ◽  
Author(s):  
Zesheng Peng ◽  
Tingfeng Wu ◽  
Yuntao Li ◽  
Zhou Xu ◽  
Shenqi Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Cycle Arrest ◽  
Glioma Cell Proliferation

Inhibition of Human Glioma Cell Proliferation Caused by Knockdown of Utrophin Using a Lentivirus-Mediated System

2016 ◽  
Vol 31 (4) ◽  
pp. 133-138 ◽  
Author(s):  
Shang-Hang Shen ◽  
Ning Yu ◽  
Hao Xu ◽  
Xi-Yao Liu ◽  
Guo-Wei Tan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Proliferation
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