scholarly journals Changes in 5-HT1A receptor in the dorsal raphe nucleus in a rat model of post-traumatic stress disorder

2011 ◽  
Author(s):  
Yu-Xiu Shi
Keyword(s):  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Dorsal Raphé

Changes of 5-HT1A receptor in the dorsal raphe nucleus in the rat model of Post-Traumatic Stress Disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 1081-1081
Author(s):  
F.F. Luo ◽  
F. Han ◽  
X.Y. Shi
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Control Group ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Dorsal Raphé

IntroductionPosttraumatic stress disorder (PTSD) is characterized mainly by symptoms of reexperiencing, avoidance and hyperarousal as a consequence of catastrophic and traumatic events that are distinguished from ordinary stressful life events. Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The dorsal raphe nucleus (DR)-serotonin (5-HT) system is dramatically affected by swim stress and has been implicated in affective disorders. The 5-HT1A receptor (5-HT1AR) is critically involved in regulating mood and anxiety levels.ObjectiveIn this study, we investigated changes in the expression of 5-HT1AR in DR of rats after SPS which may reveal part of the pathogenesis of PTSD.MethodsRats were randomly divided into 24h, 4d and 7d groups after SPS and a normal control group, 5-HT1AR expression in DR was examined using immunohistochemistry, western blotting and reverse transcription polymerase chain reaction.ResultsThe expression of 5-HT1AR in DR after SPS exposure was increased when compared to that in the control group (P < 0.05).ConclusionThese findings suggest increase of 5-HT1AR in DR of SPS rats, which may play important roles in the pathogenesis of PTSD rats.

scholarly journals Selective dopamine D3 receptor antagonism significantly attenuates stress-induced immobility in a rat model of post-traumatic stress disorder

Synapse ◽  
2018 ◽  
Vol 72 (8) ◽  
pp. e22035 ◽  
Author(s):  
Onarae V. Rice ◽  
Charles R. Ashby ◽  
Clark Dixon ◽  
William Laurenzo ◽  
Jason Hayden ◽  
...  
Keyword(s):  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Post Traumatic Stress ◽  
Dopamine D3 ◽  
Post Traumatic ◽  
Selective Dopamine

scholarly journals Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 100 ◽  
Author(s):  
Laiali Alquraan ◽  
Karem H. Alzoubi ◽  
Hana Hammad ◽  
Suzie Y. Rababa’h ◽  
Fadia Mayyas
Keyword(s):  
Fatty Acids ◽  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Memory Impairment ◽  
Stress Disorder ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Post Traumatic Stress ◽  
Post Traumatic

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can happen after exposure to a traumatic event. Post-traumatic stress disorder is common among mental health disorders that include mood and anxiety disorders. Omega-3 fatty acids (OMGs) are essential for the maintenance of brain function and prevention of cognition dysfunctions. However, the possible effect of OMG on memory impairment induced by PTSD has not been studied. In here, such an effect was explored using a rat model of PTSD. The PTSD-like behavior was induced in animals using a single-prolonged stress (SPS) rat model of PTSD (2 h restraint, 20 min forced swimming, 15 min rest, 1–2 min diethyl ether exposure). The OMG was administered orally at a dose of 100 mg omega-3 polyunsaturated fatty acid (PUFA)/100 g body weight/day. Spatial learning and memory were assessed using the radial arm water maze (RAWM) method. Changes in oxidative stress biomarkers, thiobarbituric acid reactive substances (TBARS), and brain derived neuroptrophic factor (BDNF) in the hippocampus following treatments were measured. The results revealed that SPS impaired both short- and long-term memory (p < 0.05). Use of OMG prevented memory impairment induced by SPS. Furthermore, OMG normalized SPS induced changes in the hippocampus that reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratios, the activity of catalase, glutathione peroxidase (GPx), and TBARSs levels. In conclusion, the SPS model of PTSD-like behavior generated memory impairment, whereas OMG prevented this impairment, possibly through normalizing antioxidant mechanisms in the hippocampus.

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