scholarly journals Plasma phospholipid-mediated transfer of docosahexaenoic acid from liver to brain phospholipids in type 1 and type 2 diabetic rats

2010 ◽  
Author(s):  
Willy Malaisse
Keyword(s):  
Docosahexaenoic Acid ◽  
Plasma Phospholipid ◽  
Diabetic Rats ◽  
Brain Phospholipids ◽  
Type 2 Diabetic

Brain phospholipid and triglyceride fatty acid content and pattern in Type 1 and Type 2 diabetic rats

2006 ◽  
Vol 409 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Willy J. Malaisse ◽  
Ying Zhang ◽  
Karim Louchami ◽  
Abdullah Sener ◽  
Laurence Portois ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Diabetic Rats ◽  
Triglyceride Fatty Acid ◽  
Brain Phospholipid ◽  
Type 2 Diabetic

scholarly journals Nitric oxide affects UbcH10 levels differently in type 1 and type 2 diabetic rats

2015 ◽  
Vol 196 (1) ◽  
pp. 180-189 ◽  
Author(s):  
Monica P. Rodriguez ◽  
Nick D. Tsihlis ◽  
Zachary M. Emond ◽  
Zheng Wang ◽  
Vinit N. Varu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats

2008 ◽  
Vol 441 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Liang-Ming Lee ◽  
Cheng Kuei Chang ◽  
Kai-Chun Cheng ◽  
Dai-Huang Kou ◽  
I-Min Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Muscarinic Receptor ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
M2 Muscarinic Receptor ◽  
Receptor Gene Expression ◽  
Type 2 Diabetic

Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats

2018 ◽  
Vol 29 (5) ◽  
pp. 463-467 ◽  
Author(s):  
Zahra Arab Sadeghabadi ◽  
Nasrin Ziamajidi ◽  
Roghayeh Abbasalipourkabir ◽  
Roohollah Mohseni
Keyword(s):  
Treatment Time ◽  
Diabetic Rats ◽  
Garlic Extract ◽  
Gene Expressions ◽  
Anti Inflammatory ◽  
Sirt2 Gene ◽  
Type 2 Diabetic ◽  
Liver Tissues

Abstract Background Diabetic nephropathy and liver damage are important complications of diabetes mellitus (DM). Various factors, such as sirtuins (silent information regulators or SIRTs) are associated with these complications. Sirtuins are a family of NAD+-dependent proteins, and seven types of these can be found in mammalians. In this study, we evaluated the effects of aqueous garlic extract (G) on the expressions of SIRT1 and SIRT2 genes in the kidney and liver tissues of rats with types 1 and 2 diabetes. Methods A total of 36 male Wistar rats (230–280 g) were randomly divided into six groups: C: normal control rats, D1M: type 1 diabetic rats (induced with streptozotocin, STZ), D1M+G: type 1 diabetic rats that treated with garlic extract, D2M: type 2 diabetic rats (induced with STZ and niacinamide), D2M+G: type 2 diabetic rats treated with garlic extract, and G: normal rats that received garlic extract. At the end of the treatment time, kidney and liver tissue samples were collected from all rats. The SIRT1 and SIRT2 gene expressions were determined by qRT-PCR. Results The SIRT1 and SIRT2 gene expressions in the liver and kidney tissues of diabetic rats decreased significantly compared with those in the control rats (p<0.05). After treatment with garlic extract, the gene expressions also increased significantly compared with those in the diabetic rats and are close to normal level (p<0.05). Conclusions Garlic extract increased the SIRT1 and SIRT2 gene expressions in the livers and kidneys of diabetic rats. The antioxidant and anti-inflammatory effects of garlic have been proven in many studies. Thus, it is possible that garlic – with its effects on this pathway of gene expression – can have antioxidant and anti-inflammatory effects, thus decreasing diabetic complications.

scholarly journals A Novel Sartan Derivative With Very Low Angiotensin II Type 1 Receptor Affinity Protects the Kidney in Type 2 Diabetic Rats

2008 ◽  
Vol 28 (10) ◽  
pp. 1767-1773 ◽  
Author(s):  
Yuko Izuhara ◽  
Toshio Sada ◽  
Hiroaki Yanagisawa ◽  
Hiroyuki Koike ◽  
Shuichi Ohtomo ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Diabetic Rats ◽  
Receptor Affinity ◽  
Type 2 Diabetic

Soluble dietary fibre fraction ofTrigonella foenum-graecum(fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action

2007 ◽  
Vol 97 (3) ◽  
pp. 514-521 ◽  
Author(s):  
J. M. A. Hannan ◽  
L. Ali ◽  
B. Rokeya ◽  
J. Khaleque ◽  
M. Akhter ◽  
...  
Keyword(s):  
Body Weight ◽  
Dietary Fibre ◽  
Insulin Action ◽  
Diabetic Rats ◽  
Soluble Dietary Fibre ◽  
Oral Sucrose ◽  
Carbohydrate Digestion ◽  
Type 2 Diabetic

Trigonella foenum-graecum(fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction ofT. foenum-graecumwere evaluated. Administration of SDF fraction (0·5 g/kg body weight) to normal, type 1 or type 2 diabetic rats significantly improved oral glucose tolerance. Total remaining unabsorbed sucrose in the gastrointestinal tract of non-diabetic and type 2 diabetic rats, following oral sucrose loading (2·5 g/kg body weight) was significantly increased byT. foenum-graecum(0·5 g/kg body weight). The SDF fraction suppressed the elevation of blood glucose after oral sucrose ingestion in both non-diabetic and type 2 diabetic rats. Intestinal disaccharidase activity and glucose absorption were decreased and gastrointestinal motility increased by the SDF fraction. Daily oral administration of SDF to type 2 diabetic rats for 28 d decreased serum glucose, increased liver glycogen content and enhanced total antioxidant status. Serum insulin and insulin secretion were not affected by the SDF fraction. Glucose transport in 3T3-L1 adipocytes and insulin action were increased byT. foenum-graecum.The present findings indicate that the SDF fraction ofT. foenum-graecumseeds exerts antidiabetic effects mediated through inhibition of carbohydrate digestion and absorption, and enhancement of peripheral insulin action.

Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats

2004 ◽  
Vol 4 (4) ◽  
pp. 571-576 ◽  
Author(s):  
Fatimunnisa Qadri ◽  
Eva Stark ◽  
Walter Häuser ◽  
Olaf Jöhren ◽  
Andreas Dendorfer ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Diabetic Rats ◽  
Receptor Mrna ◽  
Kinin Receptor ◽  
Type 2 Diabetic
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