scholarly journals Keratin 36, a specific marker of tongue filiform papillae, is downregulated in squamous cell carcinoma of the mobile tongue

2020 ◽  
Author(s):  
Veronika Brychtova ◽  
Philip Coates ◽  
Vaclav Hrabal ◽  
Linda Boldrup ◽  
Pavel Fabian ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Specific Marker ◽  
Filiform Papillae ◽  
Mobile Tongue

Expression of Cytokeratin Subtypes and Vimentin in Squamous Cell Carcinoma of the Floor of the Mouth and the Mobile Tongue

2001 ◽  
Vol 11 (3-4) ◽  
pp. 186-192 ◽  
Author(s):  
Lilly-Ann van der Velden ◽  
H. Ewout Schaafsma ◽  
Johannes J. Manni ◽  
Frans C.S. Ramaekers ◽  
Wim Kuijpers
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Floor Of The Mouth ◽  
Mobile Tongue

Prognostic factors in squamous cell carcinoma T1-T2 of the mobile tongue. A retrospective study of 70 cases

2007 ◽  
Vol 82 ◽  
pp. S72
Author(s):  
O. Malard ◽  
L. Bonnardot ◽  
E. Bardet ◽  
B. Piot ◽  
L. Campion ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mobile Tongue

Ultrasonography-guided interstitial brachytherapy using Iridium hairpins for stage I and II squamous cell carcinoma of the mobile tongue

Toukeibu Gan ◽  
2007 ◽  
Vol 33 (4) ◽  
pp. 460-464
Author(s):  
Minoru Fujita ◽  
Kouichi Wadasaki ◽  
Yuuji Murakami ◽  
Kanji Matsuura ◽  
Shintarou Yuki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Stage I ◽  
Interstitial Brachytherapy ◽  
Mobile Tongue

Interstitial brachytherapy and neck dissection for Stage III squamous cell carcinoma of the mobile tongue

2005 ◽  
Vol 44 (7) ◽  
pp. 709-716 ◽  
Author(s):  
Nobumaro Ihara ◽  
Hitoshi Shibuya ◽  
Ryoichi Yoshimura ◽  
Sayako Oota ◽  
Masahiko Miura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Stage Iii ◽  
Interstitial Brachytherapy ◽  
Mobile Tongue

scholarly journals Tissue Mechanics and Expression of TROP2 in Oral Squamous Cell Carcinoma with Varying Differentiation

2020 ◽  
Author(s):  
Baoping Zhang ◽  
Shuting Gao ◽  
Yiting Li ◽  
Ruiping Li ◽  
Rui Cao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Squamous Cell Carcinoma ◽  
Survival Rate ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Curve ◽  
Tumor Development ◽  
Tissue Mechanics ◽  
Specific Marker

Abstract Background Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and contributes to tumor development and invasion. The correlation between the expression of TROP2 and occurrence and development of oral squamous cell carcinoma (OSCC) remains to be understood.Methods We have investigated the role of the specific marker TROP2 in OSCC patients using a combination of biophysics approaches. Analyzed 108 OSCC patient specimens with varying degrees of differentiation using hematoxylin and eosin staining and immunohistochemistry for TROP2 expression, along with Kaplan-Meier survival curve analysis and atomic force microscopy, to understand the morphology and mechanical properties of OSCC tissues.Results In total, 34% poor differentiation underwent high TROP expression. TROP2 as risk factor about patient age (OR = 0.437, P = 0.039), tumor size (OR = 13.148, P = 0.000), TNM stage (OR = 0.141, P = 0.000) during low survival rate. Average surface roughness of low, medium, and highly differentiated OSCC tissues were 448.9 ± 54.8, 792.7 ± 83.6, and 993.0 ± 104.3 nm, respectively. The Pearson coefficient revealed a negative correlation between stiffness and TROP2 expression (r=-0.84, P < 0.01).Conclusion TROP2 expression increased with the decrease in survival rate and negatively correlated with the various degrees of differentiation and tissue mechanics. Taken together, our findings demonstrate that TROP2 may be an indicator of OSCC differentiation that leads to the altered mechanical properties (e.g., stiffness) of OSCC tissues.

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