scholarly journals Subserous invasion of VEGF-C-producing cancer cells is a possible risk factor for ileal ulceration in the non-metastatic mucosal layer during bevacizumab-combined chemotherapy for recurrent ovarian cancer: A case report

2017 ◽  
Vol 7 (5) ◽  
pp. 820-824 ◽  
Author(s):  
Takeo Matsumoto ◽  
Yasunari Mizumoto ◽  
Kyohei Nakade ◽  
Takeshi Obata ◽  
Ayumi Matsuoka ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Risk Factor ◽  
Case Report ◽  
Cancer Cells ◽  
Recurrent Ovarian Cancer ◽  
Combined Chemotherapy ◽  
Mucosal Layer

scholarly journals Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo

2019 ◽  
Vol 8 (11) ◽  
pp. e1649971 ◽  
Author(s):  
Noémie Joalland ◽  
Laura Lafrance ◽  
Thibauld Oullier ◽  
Séverine Marionneau-Lambot ◽  
Delphine Loussouarn ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Cells ◽  
T Lymphocyte ◽  
Ovarian Cancer Cells ◽  
Combined Chemotherapy

scholarly journals Epigenetic Therapy Augments Classic Chemotherapy in Suppressing the Growth of 3D High-Grade Serous Ovarian Cancer Spheroids over an Extended Period of Time

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1711
Author(s):  
Michelle Bilbao ◽  
Chelsea Katz ◽  
Stephanie L. Kass ◽  
Devon Smith ◽  
Krystal Hunter ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
3D Culture ◽  
Extended Period ◽  
Recurrent Ovarian Cancer ◽  
Epigenetic Therapy ◽  
Ovarian Cancer Cells ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Cancer Spheroids

Recurrent high-grade serous ovarian cancer (HGSC) is clinically very challenging and prematurely shortens patients’ lives. Recurrent ovarian cancer is characterized by high tumor heterogeneity; therefore, it is susceptible to epigenetic therapy in classic 2D tissue culture and rodent models. Unfortunately, this success has not translated well into clinical trials. Utilizing a 3D spheroid model over a period of weeks, we were able to compare the efficacy of classic chemotherapy and epigenetic therapy on recurrent ovarian cancer cells. Unexpectedly, in our model, a single dose of paclitaxel alone caused the exponential growth of recurrent high-grade serous epithelial ovarian cancer over a period of weeks. In contrast, this effect is not only opposite under treatment with panobinostat, but panobinostat reverses the repopulation of cancer cells following paclitaxel treatment. In our model, we also demonstrate differences in the drug-treatment sensitivity of classic chemotherapy and epigenetic therapy. Moreover, 3D-derived ovarian cancer cells demonstrate induced proliferation, migration, invasion, cancer colony formation and chemoresistance properties after just a single exposure to classic chemotherapy. To the best of our knowledge, this is the first evidence demonstrating a critical contrast between short and prolonged post-treatment outcomes following classic chemotherapy and epigenetic therapy in recurrent high-grade serous ovarian cancer in 3D culture.

Recurrent ovarian cancer metastatic to the sternum, costae, and thoracic wall after prolonged treatment with platinum-based chemotherapy: a case report and review of the literature

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 299-303
Author(s):  
G. Pavlakis ◽  
G. Mountzios ◽  
E. Terpos ◽  
A. Leivaditou ◽  
G. Papadopoulos ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Report ◽  
Alkylating Agents ◽  
Recurrent Ovarian Cancer ◽  
Thoracic Wall ◽  
Prolonged Treatment ◽  
Review Of The Literature ◽  
Tumor Spread ◽  
Platinum Based Chemotherapy ◽  
Metastatic Behavior

Sternal and costal metastases from ovarian cancer are extremely rare. We present here a case of a 47-year-old woman with thoracic wall metastasis from serous–papillary ovarian carcinoma that occurred 3 years after the initial diagnosis, although the patient had received various regimens of intense platinum-based chemotherapy. Special emphasis is given to the effects of alkylating agents, such as cisplatin and carboplatin, on the pattern of tumor spread. We also discuss the possible mechanisms through which the biologic and metastatic behavior of this tumor is expressed.

Effective weekly docetaxel for recurrent ovarian cancer: A case report

2003 ◽  
Vol 13 (5) ◽  
pp. 683-686 ◽  
Author(s):  
S. Komiyama ◽  
Y. Mizusawa ◽  
M. Onouchi ◽  
K. Takehara ◽  
A. Suzuki ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Report ◽  
Recurrent Ovarian Cancer ◽  
Weekly Docetaxel

En bloc resection of diaphragm with lung for recurrent ovarian cancer: A case report

2006 ◽  
Vol 102 (3) ◽  
pp. 596-598 ◽  
Author(s):  
Lisa A. dos Santos ◽  
Ippolito Modica ◽  
Raja M. Flores ◽  
Michael D'Angelica ◽  
Carol Aghajanian ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Report ◽  
Recurrent Ovarian Cancer ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
En Bloc

scholarly journals Occurrence of myelodysplastic syndrome during paclitaxel- and carboplatin-based chemotherapy for recurrent ovarian cancer: Case report

2013 ◽  
Vol 03 (02) ◽  
pp. 232-234
Author(s):  
Hiroshi Takagi ◽  
Satoshi Ichigo ◽  
Kazutoshi Matsunami ◽  
Haruna Takagi ◽  
Tsuneko Ikeda ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Report ◽  
Myelodysplastic Syndrome ◽  
Recurrent Ovarian Cancer ◽  
Cancer Case ◽  
Ovarian Cancer Case
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