scholarly journals Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors

2017 ◽  
Vol 7 (4) ◽  
pp. 716-720 ◽  
Author(s):  
Wen'E Cai ◽  
Xiaoyu Chen ◽  
Qingdong Pan ◽  
Shijun Zhang ◽  
Luojiao Tan ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
S180 Sarcoma

scholarly journals Synthesis and Antitumor Activity of (3-Hydroxyacrylato-O,O′) Diammineplatinum(II)

2021 ◽  
Vol 03 (01) ◽  
pp. e13-e17
Author(s):  
Yong-Zhi Shu ◽  
Jun Lin ◽  
Bao-Quan Zhu ◽  
Quan-Hai Liu ◽  
Bin Zhou ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cancer Treatment ◽  
High Resolution Mass Spectrometry ◽  
Human Tumor ◽  
Human Tumor Cell Lines ◽  
Control Drug ◽  
S180 Sarcoma ◽  
Ic50 Values ◽  
Hct 116

AbstractAs an indispensable part of cancer chemotherapy, platinum drugs still play an important role in cancer treatment. In this study, two platinum(II) complexes with Michael acceptor 3-hydroxyacrylic acid as the leaving group were synthesized from cis-diamminediiodo platinum(II) and 3-ethoxyacrylic acid. The structures of complexes 1 and 2 were confirmed by elemental analysis, infrared, 1H NMR, 13C NMR, and HRMS (high-resolution mass spectrometry). Results from MTT assay showed that complexes 1 and 2 significantly inhibited the growth of the four human tumor cell lines (HCT-116, A549, CFPAC-1, and BxPC-3) with the IC50 values of the two compounds similar to that of the control drug (oxaliplatin) on HCT-116 and A549. Besides, results from an in vivo study in a mouse S180 sarcoma model showed that complex 1 had a higher antitumor activity in comparison to oxaliplatin. In conclusion, our article indicated that complex 1 deserved further research and development in cancer treatment.

710: TNF-Related Apoptosis Inducing Ligand (TRAIL/APO-2L): A Novel Mechanism for BCG-Induced Antitumor Activity

2004 ◽  
Vol 171 (4S) ◽  
pp. 188-189
Author(s):  
Aaron T. Ludwig ◽  
Jill M. Moore ◽  
Yi Luo ◽  
Xiaohong Chen ◽  
Michael A. O’Donnell ◽  
...  
Keyword(s):  
Antitumor Activity

Antitumor activity of tricin, a flavone isolated from leaves of Casearia arborea (Salicaceae)

2017 ◽  
Author(s):  
P Sartorelli ◽  
A Santos ◽  
C Figueiredo ◽  
J Lago ◽  
M Soares
Keyword(s):  
Antitumor Activity

Adaptive NK cells with decreased antitumor activity are expanded in HBV-associated HCC

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
C Rennert ◽  
C Tauber ◽  
B Zecher ◽  
A Schuch ◽  
M Hofmann ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Nk Cells

Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities

2016 ◽  
Vol 12 (8) ◽  
pp. 311-317
Author(s):  
Kamelia El-Mahdy
Keyword(s):  
Antitumor Activity ◽  
Spectroscopic Data ◽  
Acid Hydrazide ◽  
Chloroacetic Acid ◽  
Equimolar Amount ◽  
Unsaturated Ketone ◽  
Cyanoacetic Acid ◽  
Antitumor Activities ◽  
Pyrimidine Derivatives ◽  
Cyanoacetic Acid Hydrazide

Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, respectively. The detailed synthesis, spectroscopic data, and antitumor activity for synthesized compounds were reported.

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