scholarly journals Clinical outcomes of anti-androgen withdrawal and subsequent alternative anti-androgen therapy for advanced prostate cancer following failure of initial maximum androgen blockade

2016 ◽  
Vol 4 (5) ◽  
pp. 839-844 ◽  
Author(s):  
HIROYUKI MOMOZONO ◽  
HIDEAKI MIYAKE ◽  
HIROMOTO TEI ◽  
KEN-ICHI HARADA ◽  
MASATO FUJISAWA
Keyword(s):  
Prostate Cancer ◽  
Clinical Outcomes ◽  
Advanced Prostate Cancer ◽  
Androgen Therapy ◽  
Androgen Withdrawal ◽  
Androgen Blockade

scholarly journals Effect of prior cancer on survival outcomes for patients with advanced prostate cancer

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yechen Wu ◽  
Xi Chen ◽  
Duocheng Qian ◽  
Wei Wang ◽  
Yiping Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Outcomes ◽  
Cancer Diagnosis ◽  
Advanced Prostate Cancer ◽  
Lymphocytic Leukemia ◽  
Cancer History ◽  
Non Hodgkin Lymphoma ◽  
Kaplan Meier ◽  
History Of ◽  
The Impact

Abstract Background A history of prior cancer commonly results in exclusion from cancer clinical trials. However, whether a prior cancer history has an adversely impact on clinical outcomes for patients with advanced prostate cancer (APC) remains largely unknown. We therefore aimed to investigate the impact of prior cancer history on these patients. Methods We identified patients with advanced prostate cancer diagnosed from 2004 to 2010 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance baseline characteristics. Kaplan–Meier method and the Cox proportional hazard model were utilized for survival analysis. Results A total of 19,772 eligible APC patients were included, of whom 887 (4.5 %) had a history of prior cancer. Urinary bladder (19 %), colon and cecum (16 %), melanoma of the skin (9 %) malignancies, and non-hodgkin lymphoma (9 %) were the most common types of prior cancer. Patients with a history of prior cancer had slightly inferior overall survival (OS) (AHR = 1.13; 95 % CI [1.02–1.26]; P = 0.017) as compared with that of patients without a prior cancer diagnosis. Subgroup analysis further indicated that a history of prior cancer didn’t adversely impact patients’ clinical outcomes, except in patients with a prior cancer diagnosed within 2 years, at advanced stage, or originating from specific sites, including bladder, colon and cecum, or lung and bronchus, or prior chronic lymphocytic leukemia. Conclusions A large proportion of APC patients with a prior cancer history had non-inferior survival to that of patients without a prior cancer diagnosis. These patients may be candidates for relevant cancer trials.

Monitoring the Clinical Outcomes in Advanced Prostate Cancer: What Imaging Modalities and Other Markers Are Reliable?

2013 ◽  
Vol 40 (3) ◽  
pp. 375-392 ◽  
Author(s):  
Michael J. Morris ◽  
Karen A. Autio ◽  
Ethan M. Basch ◽  
Daniel C. Danila ◽  
Steven Larson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Outcomes ◽  
Advanced Prostate Cancer ◽  
Imaging Modalities

Alternative Nonsteroidal Antiandrogen Therapy for Advanced Prostate Cancer That Relapsed After Initial Maximum Androgen Blockade

2008 ◽  
Vol 180 (3) ◽  
pp. 921-927 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Koji Okihara ◽  
Hideaki Miyake ◽  
Masato Fujisawa ◽  
Susumu Miyoshi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Antiandrogen Therapy ◽  
Androgen Blockade

Maximal androgen blockade for advanced prostate cancer

1999 ◽  
Author(s):  
Brian Schmitt ◽  
Charles Bennett ◽  
Jerome Seidenfeld ◽  
David Samson ◽  
Timothy J Wilt
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Maximal Androgen Blockade ◽  
Androgen Blockade

Anti-Androgen Therapy Suspension following Prolonged Clinical and Biochemical Response: Outcomes in a Series of Elderly Patients with Advanced Prostate Cancer

2010 ◽  
Vol 96 (2) ◽  
pp. 241-245
Author(s):  
Bruno Castagneto ◽  
Ilaria Stevani ◽  
Valentino Ferraris ◽  
Laura Giorcelli ◽  
Massimo Perachino
Keyword(s):  
Prostate Cancer ◽  
Elderly Patients ◽  
Advanced Prostate Cancer ◽  
Biochemical Response ◽  
Androgen Therapy
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