scholarly journals Isolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A case report

2016 ◽  
Vol 5 (6) ◽  
pp. 745-749 ◽  
Author(s):  
Bulent Kantarcioglu ◽  
Huseyin Saffet Bekoz ◽  
Yeliz Duvarci Ogret ◽  
Asli Cakir ◽  
Demet Kivanc ◽  
...  
Keyword(s):  
Stem Cell ◽  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Lymphoblastic Leukemia ◽  
Hematopoietic Stem ◽  
Graft Vs Host Disease ◽  
Chimerism Analysis

scholarly journals Cardiac Relapse of Acute Lymphoblastic Leukemia Following Hematopoietic Stem Cell Transplantation: A Case Report and Review of Literature

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5814
Author(s):  
Irtiza N. Sheikh ◽  
Dristhi Ragoonanan ◽  
Anna Franklin ◽  
Chandra Srinivasan ◽  
Bhiong Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Lymphoblastic Leukemia ◽  
Hematopoietic Stem ◽  
Extramedullary Relapse

Isolated extramedullary relapse of acute lymphoblastic leukemia (ALL) occurs in soft tissues and various organs outside the testis and central nervous system. Treatments such as hematopoietic stem cell transplantation and more novel modalities such as immunotherapy have eradicated ALL at extramedullary sites. In some instances, survival times for relapsed ALL at these sites are longer than those for relapsed disease involving only the bone marrow. Isolated relapse of ALL in the myocardium is rare, especially in children, making diagnosis and treatment of it difficult. More recent treatment options such as chimeric antigen receptor T-cell therapy carry a high risk of cytokine release syndrome and associated risk of worsening cardiac function. Herein we present the case of an 11-year-old boy who presented with relapsed symptomatic B-cell ALL in the myocardium following allogeneic hematopoietic stem cell transplantation. This is an unusual presentation of relapsed ALL and this case demonstrates the associated challenges in its diagnosis and treatment. The case report is followed by a literature review of the advances in treatment of pediatric leukemia and their application to extramedullary relapse of this disease in particular.

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