scholarly journals Diagnostic value of cyclin-dependent kinase/cyclin-dependent kinase inhibitor expression ratios as biomarkers of locoregional and hematogenous dissemination risks in oral squamous cell carcinoma

2015 ◽  
Vol 3 (5) ◽  
pp. 1007-1013 ◽  
Author(s):  
MASAKI NAGATA ◽  
HIROSHI KURITA ◽  
KOHYA UEMATSU ◽  
SHIN OGAWA ◽  
KATSU TAKAHASHI ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Kinase Inhibitor ◽  
Diagnostic Value ◽  
Cyclin Dependent Kinase ◽  
Hematogenous Dissemination ◽  
Cyclin Dependent Kinase Inhibitor

Inactivation of the cyclin-dependent kinase inhibitor 2A (CDKN2A ) gene in squamous cell carcinoma of the larynx

2004 ◽  
Vol 39 (3) ◽  
pp. 147-154 ◽  
Author(s):  
Robert Smigiel ◽  
Maria Sasiadek ◽  
Tomasz Krecicki ◽  
David Ramsey ◽  
Jozef Jagielski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Cdkn2a Gene ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Carcinoma Of The Larynx

scholarly journals Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma

2021 ◽  
Vol 22 (22) ◽  
pp. 12226
Author(s):  
Yu-Kai Tseng ◽  
Chun-Feng Chen ◽  
Chih-Wen Shu ◽  
Cheng-Hsin Lee ◽  
Yan-Ting Chou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Growth ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Kinase Inhibitor ◽  
Expression Levels ◽  
Sequestosome 1 ◽  
Egfr Expression ◽  
Tumor Tissues

Oral squamous cell carcinoma (OSCC) is one of the most common types of malignant tumor. Sequestosome 1 (SQSTM1) serves as an adaptor of autophagy for degrading protein aggregates. The regulation of autophagy by EGFR and its clinical impacts are indicated in various types of cancer. However, the association of EGFR and SQSTM1 in OSCC is still unknown. Our results show that the expression levels of SQSTM1 and EGFR proteins are higher in tumor tissues than in the corresponding tumor-adjacent (CTAN) tissues of OSCC patients. The expression levels of SQSTM1 were positively associated with the EGFR expression level. High co-expression of SQSTM1 and EGFR is associated with poor prognosis in OSCC patients. Moreover, SQSTM1 expression is decreased in EGFR-knockdown cells. Cell growth and invasion/migration are also decreased in cells with single/combined knockdowns of EGFR and SQSTM1 or in SQSTM1-knockdown cells without EGFR kinase inhibitor Lapatinib treatment compared to that in scrambled cells. However, cell growth and invasion/metastasis were not significantly different between the scrambled cells and SQSTM1-knockdown cells in the presence of Lapatinib. This study is the first to indicate the biological roles and clinical significance of SQSTM1 regulation by EGFR in OSCC.

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