scholarly journals Immunochemotherapy for primary central nervous system lymphoma with rituximab, methotrexate, cytarabine and dexamethasone: Retrospective analysis of 18 cases

2015 ◽  
Vol 3 (4) ◽  
pp. 949-953 ◽  
Author(s):  
JING LIU ◽  
XUE-FEI SUN ◽  
JUN QIAN ◽  
XUE-YAN BAI ◽  
HONG ZHU ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Analysis ◽  
Central Nervous System Lymphoma

scholarly journals Management of Primary Central Nervous System Lymphoma Using Intra-Arterial Chemotherapy With Osmotic Blood-Brain Barrier Disruption: Retrospective Analysis of the Sherbrooke Cohort

2021 ◽  
Vol 10 ◽  
Author(s):  
Christian Iorio-Morin ◽  
Gérald Gahide ◽  
Christophe Morin ◽  
Davy Vanderweyen ◽  
Marie-André Roy ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Analysis ◽  
Blood Brain Barrier ◽  
Central Nervous System Lymphoma ◽  
Brain Barrier ◽  
Rank Test ◽  
High Dose ◽  
Hematologic Toxicity ◽  
Blood Brain

BackgroundPrimary central nervous system lymphomas (PCNSL) are rare and aggressive CNS tumors. Current management involves high-dose methotrexate (HD-MTX) typically administered intravenously (IV), despite the existence of the blood-brain barrier (BBB), which significantly decreases its bioavailability. Cerebral intra-arterial chemotherapy (CIAC) coupled with osmotic BBB disruption (OBBBD) can theoretically circumvent this issue.MethodsWe performed a retrospective analysis of patients with newly diagnosed PCNSL treated with HD-MTX-based CIAC+OBBBD at our center between November 1999 and May 2018. OBBBD was achieved using a 25% mannitol intra-arterial infusion. Patients were followed clinically and radiologically every month until death or remission. Demographics, clinical and outcome data were collected from the medical record. All imaging studies were reviewed for evidence of complication and outcome assessment. Kaplan-Meier analyses were used to compute remission, progression-free survival (PFS) as well as overall survival times. Subgroup analyses were performed using the log rank test.ResultsForty-four patients were included in the cohort. Median follow-up was 38 months. Complete response was achieved in 34 patients (79%) at a median of 7.3 months. Actuarial median survival and PFS were 45 months and 24 months, respectively. Age, ECOG and lesion location did not impact outcome. Complications included thrombocytopenia (39%), neutropenia (20%), anemia (5%), seizures (11%), stroke (2%), and others (20%).ConclusionCIAC using HD-MTX-based protocols with OBBBD is a safe and well-tolerated procedure for the management of PCNSL. Our data suggests better PFS and survival outcomes compared to IV protocols with less hematologic toxicity and good tolerability, especially in the elderly.

Primary central nervous system lymphoma in China: a single-center retrospective analysis of 167 cases

2019 ◽  
Vol 99 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Xiang-Gui Yuan ◽  
Yu-Rong Huang ◽  
Teng Yu ◽  
Yang Xu ◽  
Yun Liang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Analysis ◽  
Central Nervous System Lymphoma ◽  
Single Center

scholarly journals Primary central nervous system lymphoma in the elderly: a multicentre retrospective analysis

2010 ◽  
Vol 151 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Mascha Schuurmans ◽  
Jacoline E. C. Bromberg ◽  
Jeanette Doorduijn ◽  
Philip Poortmans ◽  
Martin J. B. Taphoorn ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Analysis ◽  
Central Nervous System Lymphoma ◽  
The Elderly

scholarly journals The safety of resection for primary central nervous system lymphoma: a single institution retrospective analysis

2017 ◽  
Vol 132 (1) ◽  
pp. 189-197 ◽  
Author(s):  
Michael Brendan Cloney ◽  
Adam M. Sonabend ◽  
Jonathan Yun ◽  
Jingyan Yang ◽  
Fabio Iwamoto ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retrospective Analysis ◽  
Central Nervous System Lymphoma ◽  
Single Institution
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