scholarly journals A retrospective study on combination therapy with ifosfamide, adriamycin and cisplatin for progressive or recurrent uterine sarcoma

2014 ◽  
Vol 2 (4) ◽  
pp. 591-595 ◽  
Author(s):  
WATARU YAMAGAMI ◽  
NOBUYUKI SUSUMU ◽  
TOMOMI NINOMIYA ◽  
MICHIKO KUWAHATA ◽  
AYA TAKIGAWA ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Combination Therapy ◽  
Uterine Sarcoma

Brucellosis: a retrospective evaluation of 99 cases and review of brucellosis treatment

2008 ◽  
Vol 38 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Neşe Demirtürk ◽  
Tuna Demirdal ◽  
Nurettin Erben ◽  
Serap Demir ◽  
Zerrin Asci ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Combination Therapy ◽  
Clinical Sign ◽  
Epidural Abscess ◽  
Retrospective Evaluation ◽  
University Hospitals ◽  
Serological Tests ◽  
Frequent Symptom ◽  
Clinical Presentations

This retrospective study was performed in two university hospitals between January 2002 and 2006. Ninety-nine brucellosis patients were included in the study. These patients were classified as acute (91), chronic (4) and relapse (4) according to their clinical presentations and serological tests. Brucella bacteria were isolated in the blood of 17 (17.2%) cases. The most frequent symptom and clinical sign was fever. The osteoarticular complications were found in 17 patients (17.2%). Four of them were complicated with epidural abscess the same time. Two (2.2%) had meningitis, two (2.2%) had epididymoorchitis, three (3.3%) had skin rashes and one (1.1%) had hepatitis. Three of the acute brucellosis patients were pregnant. Rifampin and doxycycline combination therapy had been administered to most of the patients with acute and relapse brucellosis. However, complicated and chronic brucellosis cases were given different treatment combinations. This study reviews brucellosis therapy choices.

scholarly journals The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia

2021 ◽  
Vol 33 (3) ◽  
pp. 200
Author(s):  
Oki Suwarsa ◽  
Fatima Aulia Khairani ◽  
Syawalika Ulya Isneny ◽  
Erda Avriyanti ◽  
Hartati Purbo Dharmadji ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Adverse Effects ◽  
Combination Therapy ◽  
Combination Treatment ◽  
Psoriasis Vulgaris ◽  
Severity Index ◽  
Dermatology Clinic ◽  
Significant Difference ◽  
Pasi Score

Background: Methotrexate (MTX) and cyclosporine have been used as effective systemic mono-therapy for psoriasis. Several factors are considered to switch monotherapy to combination therapy because monotherapy is no longer effective and has higher side effects. Hence,clinicians have avoided systemic therapy combinations due to its toxicity. However, some studies showed that this combination therapy could be usedeffectively for psoriasis patients. Purpose: This study aimed to analyze the efficacy and adverse effects of systemic MTX and cyclosporine combination therapy in Indonesian psoriasis vulgaris patients. Methods: The retrospective study assessed the effectiveness of 3 monthsmono-therapyand combination therapy of systemic MTX and cyclosporine in psoriasisvulgaris patients from 2016–2017 in Dermatology Clinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia. Result: Psoriasis area and severity index (PASI) score 90 were achieved in the group MTX (50%) and cyclosporine group (50%), while none in the combination group.However, eight patients (50%) in group MTX and cyclosporine reached the primary endpoint of PASI 50. One patient in cyclosporine group had adverse effects on kidney profiles. Nonetheless, other patients had no biochemical changes. But, there was no significant difference in the change of PASI between each group (p=0.102). Conclusion: We propose that combination therapy of MTX and cyclosporine is relatively safe and efficacious in treating Indonesian psoriasis vulgaris patients. This combination treatment isas effective as MTX or cyclosporinemono-therapy.

Carboplatin and epirubicin combination therapy for advanced malignant epithelial skin tumors: Retrospective study of six patients

2018 ◽  
Vol 45 (7) ◽  
pp. 874-875 ◽  
Author(s):  
Yoshio Nakamura ◽  
Keiji Tanese ◽  
Ikuko Hirai ◽  
Yutaka Kawakami ◽  
Takeru Funakoshi
Keyword(s):  
Retrospective Study ◽  
Combination Therapy ◽  
Skin Tumors ◽  
Epirubicin Combination

scholarly journals S-1 plus cisplatin combination therapy in patients with urachal carcinoma: A retrospective study

2017 ◽  
Vol 28 ◽  
pp. x84 ◽  
Author(s):  
R. Oki ◽  
C. Kondoh ◽  
Y. Miura ◽  
Y. Ozaki ◽  
Y. Tanabe ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Combination Therapy ◽  
Urachal Carcinoma

scholarly journals The Safety and Efficacy of Combination Therapy of Sorafenib and Radiotherapy for Advanced Hepatocellular Carcinoma: A Retrospective Study

2018 ◽  
Vol 57 (10) ◽  
pp. 1345-1353 ◽  
Author(s):  
Yoshiyuki Wada ◽  
Yuko Takami ◽  
Hajime Matsushima ◽  
Masaki Tateishi ◽  
Tomoki Ryu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Combination Therapy ◽  
Advanced Hepatocellular Carcinoma ◽  
Safety And Efficacy

scholarly journals Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy

2020 ◽  
Vol 13 (1) ◽  
pp. 373-378 ◽  
Author(s):  
Yuri Nakao ◽  
Satoshi Tamauchi ◽  
Nobuhisa Yoshikawa ◽  
Shiro Suzuki ◽  
Hiroaki Kajiyama ◽  
...  
Keyword(s):  
Lymph Node ◽  
Combination Therapy ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Uterine Cervix ◽  
Posterior Wall ◽  
Complete Response ◽  
Uterine Sarcoma ◽  
Small Cell ◽  
Lymph Node Sampling

We report a case of recurrent small cell carcinoma of the uterine cervix that showed a complete response to paclitaxel, carboplatin, and bevacizumab (TC + Bev) combination therapy. Small cell carcinoma of the uterine cervix is extremely rare, with an incidence of only 1.3% in Japan, and a poor outcome. The patient was a 62-year-old woman with a chief complaint of irregular vaginal bleeding. Magnetic resonance imaging showed a 10-cm irregular mass from the uterine corpus’s posterior wall to the cervix. Abdominal total hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node sampling were performed for suspected uterine sarcoma. Histopathological findings revealed small cell carcinoma with lymph node metastasis. Although 6 cycles of etoposide + cisplatin were performed, para-aortic lymph node recurrence was found 3 months after chemotherapy. Subsequently, the patient received 8 cycles of TC + Bev, which eliminated the metastases. The patient is currently alive at 24 months.

scholarly journals Combination therapy with beraprost sodium and aspirin for acute ischemic stroke: a single-center retrospective study

2019 ◽  
Vol 47 (7) ◽  
pp. 3014-3024 ◽  
Author(s):  
De Cai ◽  
Xiao-Pu Chen ◽  
Dun-Can Wei ◽  
Qian Zhang ◽  
Si-Qia Chen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Retrospective Study ◽  
Combination Therapy ◽  
Adverse Events ◽  
Acute Ischemic Stroke ◽  
Blood Coagulation ◽  
Control Group ◽  
Single Center ◽  
Beraprost Sodium ◽  
Significant Difference

Objectives To evaluate the effectiveness and safety of the combination of beraprost sodium (BPS) and aspirin in patients with acute ischemic stroke (AIS). Methods There were 384 patients with AIS enrolled in this single-center, retrospective study. The BPS group comprised patients who received combination therapy with BPS and aspirin, and the control group comprised those who received only aspirin. Primary measurements were glomerular filtration rate (GFR), cystatin-c (Cys-C), National Institute of Health Stroke Scale (NIHSS) score, modified activities of daily living index (MBI), modified Rankin scale (mRS), and blood coagulation indexes. Recurrence and adverse events were recorded. Results There were no significant differences in patient characteristics at baseline between the two groups. GFR and Cys-C levels increased in the BPS group compared with the control group. After treatment, the NIHSS and mRS score were significantly lower in the BPS group compared with the control group, whereas the MBI scores were significantly higher in the BPS group compared with the control group. There was no significant difference in blood coagulation between the two groups. There were no serious adverse events in either group. Conclusions Combination therapy with BPS and aspirin may be a safe and effective treatment for AIS.

scholarly journals Acute kidney injury risk with piperacillin‐tazobactam and vancomycin combination therapy: single centre retrospective study

2020 ◽  
Vol 50 (6) ◽  
pp. 514-518
Author(s):  
Emma McLaren ◽  
Iouri Banakh ◽  
Sok Leng Cam ◽  
Grace Loh ◽  
Darshana Meanger ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Retrospective Study ◽  
Combination Therapy ◽  
Injury Risk ◽  
Kidney Injury ◽  
Single Centre
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