scholarly journals Long-term expression of rAAV2-hIL15 enhances immunoglobulin production and lymphokine-activated killer cell-mediated human glioblastoma cell death

2013 ◽  
Vol 1 (2) ◽  
pp. 321-325 ◽  
Author(s):  
GIOU-TENG YIANG ◽  
RUEY-HWANG CHOU ◽  
WEI-JUNG CHANG ◽  
CHYOU-WEI WEI ◽  
YUNG-LUEN YU
Keyword(s):  
Cell Death ◽  
Killer Cell ◽  
Glioblastoma Cell ◽  
Immunoglobulin Production ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Lymphokine Activated Killer Cell

Gastrin inhibits motility, decreases cell death levels and increases proliferation in human glioblastoma cell lines

1998 ◽  
Vol 37 (3) ◽  
pp. 373-382 ◽  
Author(s):  
Christophe De Hauwer ◽  
Isabelle Camby ◽  
Francis Darro ◽  
Isabelle Migeotte ◽  
Christine Decaestecker ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Lines ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines

scholarly journals Propagation of a protease-resistant form of prion protein in long-term cultured human glioblastoma cell line T98G

2004 ◽  
Vol 85 (11) ◽  
pp. 3449-3457 ◽  
Author(s):  
Yutaka Kikuchi ◽  
Tomoshi Kakeya ◽  
Ayako Sakai ◽  
Kosuke Takatori ◽  
Naoto Nakamura ◽  
...  
Keyword(s):  
Cell Line ◽  
Prion Protein ◽  
Cellular Prion Protein ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Resistant Form

Human prion diseases, such as Creutzfeldt–Jakob disease (CJD), a lethal, neurodegenerative condition, occur in sporadic, genetic and transmitted forms. CJD is associated with the conversion of normal cellular prion protein (PrPC) into a protease-resistant isoform (PrPres). The mechanism of the conversion has not been studied in human cell cultures, due to the lack of a model system. In this study, such a system has been developed by culturing cell lines. Human glioblastoma cell line T98G had no coding-region mutations of the prion protein gene, which was of the 129 M/V genotype, and expressed endogenous PrPC constitutively. T98G cells produced a form of proteinase K (PK)-resistant prion protein fragment following long-term culture and high passage number; its deglycosylated form was approximately 18 kDa. The PK-treated PrPres was detected by immunoblotting with the mAb 6H4, which recognizes residues 144–152, and a polyclonal anti-C-terminal antibody, but not by the mAb 3F4, which recognizes residues 109–112, or the anti-N-terminal mAb HUC2-13. These results suggest that PrPC was converted into a proteinase-resistant form of PrPres in T98G cells.

Cell death induced in a human glioblastoma cell line by p(65)+Be neutrons combined with cisplatin

Life Sciences ◽  
2006 ◽  
Vol 79 (6) ◽  
pp. 513-518 ◽  
Author(s):  
Sami Benzina ◽  
Barbara Fischer ◽  
Anne Miternique-Grosse ◽  
Patrick Dufour ◽  
Jean-Marc Denis ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell

271 PDGFR and IGF-1R inhibitors induce G2/M arrest and subsequent cell death in human glioblastoma cell lines and primary cultures

2015 ◽  
Vol 51 ◽  
pp. S50
Author(s):  
M. Saceda ◽  
E. Carrasco-Garcia ◽  
L. Mayor-Lopez ◽  
E. Tristante ◽  
M. Carballo-Santana ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Lines ◽  
Primary Cultures ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines
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