COOPERATIVE INHIBITORY EFFECT OF N,N,N-TRIMETHYLSPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE, CO-INCORPORATED IN LIPOSOMES, ON B16 MELANOMA CELL METASTASIS - CELL-MEMBRANE SIGNALING AS A TARGET IN CANCER-THERAPY .4.

1995 ◽  
Author(s):  
YS PARK ◽  
FQ RUAN ◽  
SI HAKOMORI ◽  
Y IGARASHI
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Melanoma Cell ◽  
Inhibitory Effect ◽  
B16 Melanoma ◽  
Cell Metastasis ◽  
B16 Melanoma Cell ◽  
Sphingosine 1 Phosphate ◽  
Membrane Signaling

Suppressive Mechanism of Salmosin, a Novel Disintegrin in B16 Melanoma Cell Metastasis

2000 ◽  
Vol 275 (1) ◽  
pp. 169-173 ◽  
Author(s):  
In-Cheol Kang ◽  
Doo-Sik Kim ◽  
Yangsoo Jang ◽  
Kwang-Hoe Chung
Keyword(s):  
Melanoma Cell ◽  
B16 Melanoma ◽  
Cell Metastasis ◽  
B16 Melanoma Cell ◽  
Suppressive Mechanism

scholarly journals Suppressive Effect of Juzen-Taiho-To on Lung Metastasis of B16 Melanoma CellsIn Vivo

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Takako Matsuda ◽  
Katsuhiko Maekawa ◽  
Kazuhito Asano ◽  
Tadashi Hisamitsu
Keyword(s):  
Tumor Cell ◽  
Lung Metastasis ◽  
Melanoma Cell ◽  
Inhibitory Action ◽  
Nk Cell ◽  
B16 Melanoma ◽  
Nkt Cell ◽  
Cell Metastasis ◽  
B16 Melanoma Cell ◽  
Tumor Cell Metastasis

Juzen-Taiho-To (JTT) is well known to be one of Kampo (Japanese herbal) medicine consisted of 10 component herbs and used for the supplemental therapy of cancer patients with remarkably success. However, the precise mechanisms by which JTT could favorably modify the clinical conditions of cancer patients are not well defined. The present study, therefore, was undertaken to examine the possible mechanisms of JTT on prevention of cancer metastasis using experimental mouse model. JTT was well mixed with rodent chow at concentrations of either 0.2 or 1.0%, and administered orallyad libitum, which was started 1 week before tumor cell injection and continue throughout the experiment. Oral administration of JTT at concentration 0.2 and 1.0% into C57BL/6 male mice significantly inhibited tumor metastasis in lungs, which was induced by the intravenous injection of 2 × 105B16 melanoma cell. JTT at a concentration of 1.0% also significantly suppressed lung metastasis of B16 melanoma cell from hind footpad in C57BL/6 mice. In the second part of experiments, the influence of the depression of natural killer (NK) cell, natural killer T (NKT) cell and several types of cytokines on JTT-mediated inhibition of tumor cell metastasis. Intraperitoneal injection of anti asialo-GM1 antibody against NK cells and anti NK-1.1 monoclonal antibody (mAb) to NKT cells abrogated the inhibitory action of JTT on lung metastasis of B16 melanoma cells. Although intraperitoneal administration of anti-IFN-γ mAb scarcely affected the inhibitory action of JTT on tumor cell metastasis, injection of amrinone, which used for IL-12 suppression, significantly decreased the ability of JTT to prevent tumor cell metastasis. These results strongly suggest that oral administration of JTT caused increase in the production of IL-12, which is responsible for the activation of both NK cell and NKT cell, in the lungs and results in inhibition of B16 melanoma cell metastasis in the lungs.

Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell

2011 ◽  
Vol 226 (7) ◽  
pp. 1915-1925 ◽  
Author(s):  
Min-Bin Chen ◽  
Wen-Xiang Shen ◽  
Yun Yang ◽  
Xiao-Yang Wu ◽  
Jin-Hua Gu ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Melanoma Cell ◽  
Cell Apoptosis ◽  
B16 Melanoma ◽  
B16 Melanoma Cell ◽  
Amp Activated Protein Kinase

scholarly journals Photodynamic treatment induces cell death by apoptosis or autophagy depending on the melanin content in two B16 melanoma cell lines

2012 ◽  
Vol 29 (3) ◽  
pp. 1196-1200 ◽  
Author(s):  
AGNÈS SPARSA ◽  
SOLENN BELLATON ◽  
THOMAS NAVES ◽  
MARIE-ODILE JAUBERTEAU ◽  
JEAN-MARIE BONNETBLANC ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Lines ◽  
Melanoma Cell ◽  
B16 Melanoma ◽  
Melanin Content ◽  
Photodynamic Treatment ◽  
B16 Melanoma Cell ◽  
Melanoma Cell Lines

Beta-adrenergic receptors of B16 melanoma cell

1983 ◽  
Vol 275 (6) ◽  
pp. 415-416 ◽  
Author(s):  
M. Tsuji ◽  
T. Kuno ◽  
C. Tanaka ◽  
M. Ichihashi ◽  
Y. Mishima
Keyword(s):  
Melanoma Cell ◽  
Adrenergic Receptors ◽  
B16 Melanoma ◽  
Beta Adrenergic Receptors ◽  
Beta Adrenergic ◽  
B16 Melanoma Cell

scholarly journals Diterpenoid B derived from Plectranthus excisus inhibits the melanoma cell cycle in the B16 melanoma cell line

2015 ◽  
Vol 12 (3) ◽  
pp. 4578-4583 ◽  
Author(s):  
YA-NAN LIU ◽  
JUN-LIAN GU ◽  
MENG-SHI MA ◽  
HUA GUO ◽  
LONG LIU ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
B16 Melanoma ◽  
B16 Melanoma Cell

scholarly journals Ligand-dependent Inhibition of B16 Melanoma Cell Migration and Invasion via Endogenous S1P2G Protein-coupled Receptor

2003 ◽  
Vol 278 (35) ◽  
pp. 32841-32851 ◽  
Author(s):  
Kayo Arikawa ◽  
Noriko Takuwa ◽  
Hironori Yamaguchi ◽  
Naotoshi Sugimoto ◽  
Joji Kitayama ◽  
...  
Keyword(s):  
Cell Migration ◽  
Melanoma Cell ◽  
B16 Melanoma ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
B16 Melanoma Cell ◽  
Dependent Inhibition

scholarly journals Doxorubicin cellular pharmacokinetics and DNA breakage in a multi-drug resistant B16 melanoma cell line

1988 ◽  
Vol 57 (2) ◽  
pp. 142-146 ◽  
Author(s):  
R Supino ◽  
M Mariani ◽  
G Capranico ◽  
A Colombo ◽  
G Parmiani
Keyword(s):  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
B16 Melanoma ◽  
Drug Resistant ◽  
Dna Breakage ◽  
Cellular Pharmacokinetics ◽  
B16 Melanoma Cell

Saikosaponin b2 induces differentiation and apoptosis in cultured b16 melanoma cell line

1997 ◽  
Vol 7 (Supplement 1) ◽  
pp. S99
Author(s):  
Z P Zong ◽  
K Fujikawa-Yamamoto ◽  
M Tanino ◽  
M Murakami ◽  
N Yamaguchi ◽  
...  
Keyword(s):  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
B16 Melanoma ◽  
B16 Melanoma Cell
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