FLOW CYTOMETRIC CELLULAR DNA CONTENT AND LYMPH-NODE METASTASIS IN SQUAMOUS-CELL CARCINOMA OF THE ORAL CAVITY

Author(s):  
J HEMMER ◽  
J KREIDLER ◽  
WFP VANHEERDEN ◽  
EJ RAUBENHEIMER ◽  
E SCHON
Tumor Biology ◽  
2008 ◽  
Vol 29 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Fernanda Oliveira Ferreira ◽  
Fernanda Luiza Leite Ribeiro ◽  
Aline Carvalho Batista ◽  
Cláudio Rodrigues Leles ◽  
Rita de Cassia Goncalves Alencar ◽  
...  

2021 ◽  
Vol 10 (4) ◽  
pp. 3442-3445
Author(s):  
Anmol Taneja

Squamous cell carcinoma and Adenocarcinoma are common subtypes of carcinoma of oral cavity. More than six lakh cases of cancers of head and neck are being diagnosed globally every year and worldwide, it’s the 6th most common cancer. Head and Neck cancers mostly take origin from epithelial lining of oral cavity, oropharynx, larynx and hypopharynx and 90% of them morphologically is predominantly squamous cell carcinoma. OSCC has a poor prognosis, the reason being metastasis to lymph nodes and its recurrence. So, the identification of specific markers with metastasis to lymph nodes should be done for early and specific diagnosis. Normal and neoplastic mesenchymal cells contain vimentin as major protein constituent of intermediate filaments. Vimentin does not show expression usually in non-neoplastic epithelial cells, but shows expression in mesenchymal cells. Vimentin as a marker of epithelial to mesenchymal transitionis used in diagnosing lymph node metastasis in cases of OSCC.


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