INDUCTION BY HUMAN INTERFERON AND MURINE H-2L(D) GENE OF THE SURFACE EXPRESSION OF ENDOGENOUS HLA CLASS-I FREE HEAVY-CHAINS IN HCT HUMAN COLON-CARCINOMA CELLS, DEFICIENT IN BETA-2-MICROGLOBULIN

Author(s):  
MM SIMILE ◽  
L CALORINI ◽  
MS RYAN ◽  
S GATTONICELLI
1989 ◽  
Vol 169 (1) ◽  
pp. 309-314 ◽  
Author(s):  
F Momburg ◽  
S Koch

Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule. In all of these tumors, beta 2m protein and mRNA were found to be completely absent from the neoplastic cells, whereas free H chains and their respective mRNAs were present in abundance in the tumor cell cytoplasm. The selective abrogation of beta 2m expression represents a unique mechanism leading to a complete loss of class I antigen surface expression in vivo.


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2014 ◽  
Vol 80 (16) ◽  
Author(s):  
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M Tomczyk ◽  
A Wiater ◽  
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M Pleszczynska ◽  
...  

1990 ◽  
Vol 265 (32) ◽  
pp. 19980-19989
Author(s):  
R V Iozzo ◽  
I Kovalszky ◽  
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P K Schick ◽  
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2009 ◽  
Vol 15 (9) ◽  
pp. 1079 ◽  
Author(s):  
Piet Habbel ◽  
Karsten H Weylandt ◽  
Katja Lichopoj ◽  
Johannes Nowak ◽  
Martin Purschke ◽  
...  

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