scholarly journals Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells

2007 ◽  
Author(s):  
Toyotaka Iguchi ◽  
Yoshitaka Miyakawa ◽  
Kaori Saito ◽  
Chika Nakabayashi ◽  
Makoto Nakanishi ◽  
...  
Keyword(s):  
Dna Damage ◽  
S Phase ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Phase Arrest ◽  
Human Osteosarcoma Cells ◽  
S Phase Arrest

scholarly journals Erratum to: Induction of G1/S Phase Arrest and Apoptosis by Quercetin in Human Osteosarcoma Cells

2011 ◽  
Vol 34 (6) ◽  
pp. 1035-1035
Author(s):  
Doo Kyo Suh ◽  
Eul Jae Lee ◽  
Hyung Chan Kim ◽  
Jeong Hee Kim
Keyword(s):  
S Phase ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Phase Arrest ◽  
Human Osteosarcoma Cells ◽  
S Phase Arrest

Induction of G1/S phase arrest and apoptosis by quercetin in human osteosarcoma cells

2010 ◽  
Vol 33 (5) ◽  
pp. 781-785 ◽  
Author(s):  
Doo Kyo Suh ◽  
Eul Jae Lee ◽  
Hyung Chan Kim ◽  
Jeong Hee Kim
Keyword(s):  
S Phase ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Phase Arrest ◽  
Human Osteosarcoma Cells ◽  
S Phase Arrest

scholarly journals GADD45a Regulates Olaquindox-Induced DNA Damage and S-Phase Arrest in Human Hepatoma G2 Cells via JNK/p38 Pathways

Molecules ◽  
2017 ◽  
Vol 22 (1) ◽  
pp. 124 ◽  
Author(s):  
Daowen Li ◽  
Chongshan Dai ◽  
Xiayun Yang ◽  
Bin Li ◽  
Xilong Xiao ◽  
...  
Keyword(s):  
Dna Damage ◽  
S Phase ◽  
Human Hepatoma ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
G2 Cells

scholarly journals Schizosaccharomyces pombe Checkpoint Response to DNA Interstrand Cross-Links

2003 ◽  
Vol 23 (13) ◽  
pp. 4728-4737 ◽  
Author(s):  
Sarah Lambert ◽  
Sarah J. Mason ◽  
Louise J. Barber ◽  
John A. Hartley ◽  
Jackie A. Pearce ◽  
...  
Keyword(s):  
Dna Damage ◽  
Schizosaccharomyces Pombe ◽  
Mammalian Cells ◽  
Excision Repair ◽  
S Phase ◽  
Repair Gene ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
Interstrand Cross Links ◽  
Cross Links

ABSTRACT Drugs that produce covalent interstrand cross-links (ICLs) in DNA remain central to the treatment of cancer, but the cell cycle checkpoints activated by ICLs have received little attention. We have used the fission yeast, Schizosaccharomyces pombe, to elucidate the checkpoint responses to the ICL-inducing anticancer drugs nitrogen mustard and mitomycin C. First we confirmed that the repair pathways acting on ICLs in this yeast are similar to those in the main organisms studied to date (Escherichia coli, budding yeast, and mammalian cells), principally nucleotide excision repair and homologous recombination. We also identified and disrupted the S. pombe homologue of the Saccharomyces cerevisiae SNM1/PSO2 ICL repair gene and found that this activity is required for normal resistance to cross-linking agents, but not other forms of DNA damage. Survival and biochemical analysis indicated a key role for the “checkpoint Rad” family acting through the chk1-dependent DNA damage checkpoint in the ICL response. Rhp9-dependent phosphorylation of Chk1 correlates with G2 arrest following ICL induction. In cells able to bypass the G2 block, a second-cycle (S-phase) arrest was observed. Only a transient activation of the Cds1 DNA replication checkpoint factor occurs following ICL formation in wild-type cells, but this is increased and persists in G2 arrest-deficient mutants. This likely reflects the fraction of cells escaping the G2 damage checkpoint and arresting in the subsequent S phase due to ICL replication blocks. Disruption of cds1 confers increased resistance to ICLs, suggesting that this second-cycle S-phase arrest might be a lethal event.

scholarly journals Defective S Phase Chromatin Assembly Causes DNA Damage, Activation of the S Phase Checkpoint, and S Phase Arrest

2003 ◽  
Vol 11 (2) ◽  
pp. 341-351 ◽  
Author(s):  
Xiaofen Ye ◽  
Alexa A Franco ◽  
Hidelita Santos ◽  
David M Nelson ◽  
Paul D Kaufman ◽  
...  
Keyword(s):  
Dna Damage ◽  
S Phase ◽  
Chromatin Assembly ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
S Phase Checkpoint
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