scholarly journals The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial growth factor receptor 2 signaling pathway

2018 ◽  
Author(s):  
Jiyoon Seok ◽  
Soo‑Hyun Yoon ◽  
Sun‑Hee Lee ◽  
Jong Hwa Jung ◽  
You Mie Lee
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Angiogenic Activity ◽  
Endothelial Growth Factor

Discovery of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors

MedChemComm ◽  
2015 ◽  
Vol 6 (7) ◽  
pp. 1375-1380 ◽  
Author(s):  
Yongcong Lv ◽  
Mengyuan Li ◽  
Sufen Cao ◽  
Linjiang Tong ◽  
Ting Peng ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Tumor Angiogenesis ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has emerged as an attractive strategy for the treatment of cancer.

scholarly journals Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis

2021 ◽  
Vol 11 ◽  
Author(s):  
Bochao Geng ◽  
Yuanzhang Zhu ◽  
Yingying Yuan ◽  
Jingyi Bai ◽  
Zhizhi Dou ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Vasculogenic Mimicry ◽  
Choroidal Melanoma ◽  
Growth Factor Receptor ◽  
Migration And Invasion ◽  
Vascular Endothelial ◽  
Related Proteins ◽  
Endothelial Growth Factor

Angiogenesis and vasculogenic mimicry (VM) are considered to be the main processes to ensure tumor blood supply during the proliferation and metastasis of choroidal melanoma (CM). The traditional antimalarial drug artesunate (ART) has some potential anti-CM effects; however, the underlying mechanisms remain unclarified. Recent studies have shown that the Wnt5a/calmodulin-dependent kinase II (CaMKII) signaling pathway has a close correlation with angiogenesis and VM formation. This study demonstrated that ART eliminated VM formation by inhibiting the aforementioned signaling pathway in CM cells. The microvessel sprouting of the mouse aortic rings and the microvessel density of chicken chorioallantoic membrane (CAM) decreased significantly after ART treatment. VM formation assay and periodic acid schiff (PAS) staining revealed that ART inhibited VM formation in CM. Moreover, ART downregulated the expression levels of the angiogenesis-related proteins vascular endothelial growth factor receptor (VEGFR) 2, platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor (VEGF) A, and VM-related proteins ephrin type-A receptor (EphA) 2 and vascular endothelial (VE)-cadherin. The expression of hypoxia-inducible factor (HIF)-1α, Wnt5a, and phosphorylated CaMKII was also downregulated after ART treatment. In addition, we further demonstrated that ART inhibited the proliferation, migration, and invasion of OCM-1 and C918 cells. Collectively, our results suggested that ART inhibited angiogenesis and VM formation of choroidal melanoma likely by regulating the Wnt5a/CaMKII signaling pathway. These findings further supported the feasibility of ART for cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document