scholarly journals ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel

2018 ◽  
Author(s):  
Shou Li ◽  
Xiaoyun Zhao ◽  
Shijie Chang ◽  
Yanqiu Li ◽  
Min Guo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Rna Silencing ◽  
Small Interfering Rna ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Drug Resistant ◽  
Interfering Rna

Kuguacin J isolated from bitter melon leaves modulates paclitaxel sensitivity in drug-resistant human ovarian cancer cells

2017 ◽  
Vol 71 (4) ◽  
pp. 693-702 ◽  
Author(s):  
Pornsiri Pitchakarn ◽  
Sonthaya Umsumarng ◽  
Sariya Mapoung ◽  
Pisamai Ting ◽  
Piya Temviriyanukul ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Bitter Melon ◽  
Drug Resistant

Targeted Delivery of siRNA to Ovarian Cancer Cells Using Functionalized Graphene Oxide

Nano LIFE ◽  
2018 ◽  
Vol 08 (01) ◽  
pp. 1850001 ◽  
Author(s):  
Shibin Du ◽  
Yunfei Wang ◽  
Junping Ao ◽  
Kai Wang ◽  
Zhiying Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Graphene Oxide ◽  
Gene Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Small Interfering Rna ◽  
Folate Receptor ◽  
Ovarian Cancer Cells ◽  
Functionalized Graphene Oxide ◽  
Interfering Rna

Ovarian cancer is the highest mortality rate of all cancers in the female reproductive system. Over the past decades, small interfering RNA (si RNA) has been explored as a promising therapeutic candidate for gene therapy. However, its clinical application is limited by the lack of safe and efficient methods for gene delivery. Graphene oxide (GO) was modified with polyethylene glycol (PEG), polyethylenimine (PEI) and folic acid (FA), for targeted delivery of small interfering RNA (siRNA) that inhibits ovarian cancer cell growth, and the efficacy of such complex was evaluated by a series of in vitro experiments. The synthesized vehicle PEG-GO-PEI-FA was characterized by atomic force microscopy (AFM), Malvern particle size analyzer, UV-visible spectroscopy and Fourier transform infrared spectroscopy (FTIR), and the results showed that PEG, PEI and FA could be covalently grafted to GO surface, forming PEG-GO-PEI-FA particles with a size of [Formula: see text][Formula: see text]nm and a potential of 14.7[Formula: see text]mV. Agarose-gel electrophoresis demonstrated that siRNA can be adsorbed onto the surface of PEG-GO-PEI-FA by electrostatic interaction. Laser confocal microscopy demonstrated that siRNA-adsorbed PEG-GO-PEI-FA could be target into folate receptor (FR)-overexpressing ovarian cancer cells. Compared to the PEG-GO-PEI/siRNA without folate modification, PEG-GO-PEI-FA/siRNA showed more pronounced inhibitory effect on growth of ovarian cancer cells. In conclusion, we have successfully synthesized a vector that is safe, efficient and specific to target tumor cell for gene delivery.

Silencing pathways that underlie platinum resistance in ovarian cancer cells using small interfering RNA

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 5117-5117 ◽  
Author(s):  
A. Elahi ◽  
M. A. Martino ◽  
J. Cragun ◽  
M. I. Goldberg ◽  
M. S. Hoffman ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Small Interfering Rna ◽  
Ovarian Cancer Cells ◽  
Platinum Resistance ◽  
Silencing Pathways ◽  
Interfering Rna

Exosomal delivery of berry anthocyanidins for the management of ovarian cancer

2017 ◽  
Vol 8 (11) ◽  
pp. 4100-4107 ◽  
Author(s):  
Farrukh Aqil ◽  
Jeyaprakash Jeyabalan ◽  
Ashish K. Agrawal ◽  
Al-Hassan Kyakulaga ◽  
Radha Munagala ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Drug Resistant ◽  
Therapeutic Activity

The exosomal formulation of berry Anthos elicits potent therapeutic activity against both the drug-sensitive and drug-resistant human ovarian cancer cells in vitro and in vivo.

Synthetic Naphthoflavonoids Showing Inhibitory Effects on Clonogenicity against Cisplatin-Resistant A2780/Cis Human Ovarian Cancer Cells

2015 ◽  
Vol 12 (8) ◽  
pp. 628-639
Author(s):  
Yearam Jung ◽  
Soon Young Shin ◽  
Yeonjoong Yong ◽  
Hyuk Yoon ◽  
Seunghyun Ahn ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Inhibitory Effects
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