scholarly journals Interaction of S100A1 with LATS1 promotes cell growth through regulation of the Hippo pathway in hepatocellular carcinoma

2018 ◽  
Author(s):  
Qingping Guo ◽  
Jiale Wang ◽  
Zeyu Cao ◽  
Yongchang Tang ◽  
Chao Feng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Hippo Pathway ◽  
The Hippo Pathway

scholarly journals Staurosporine targets the Hippo pathway to inhibit cell growth

2018 ◽  
Vol 10 (3) ◽  
pp. 267-269
Author(s):  
Xueyan Ma ◽  
Peixue Li ◽  
Peihao Chen ◽  
Jinhui Li ◽  
Hongling Huang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Hippo Pathway ◽  
Inhibit Cell Growth ◽  
The Hippo Pathway

The Hippo pathway in hepatocellular carcinoma: Non-coding RNAs in action

2017 ◽  
Vol 400 ◽  
pp. 175-182 ◽  
Author(s):  
Xuan Shi ◽  
Hai-Rong Zhu ◽  
Tao-Tao Liu ◽  
Xi-Zhong Shen ◽  
Ji-Min Zhu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hippo Pathway ◽  
Non Coding Rnas ◽  
The Hippo Pathway

scholarly journals Hepatic Hippo signaling inhibits development of hepatocellular carcinoma

2020 ◽  
Vol 26 (4) ◽  
pp. 742-750
Author(s):  
Yuchen Liu ◽  
Xiaohui Wang ◽  
Yingzi Yang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Hippo Pathway ◽  
Hepatocyte Proliferation ◽  
Binding Motif ◽  
Hippo Signaling ◽  
Human Liver Cancer ◽  
Kinase Cascade ◽  
The Hippo Pathway

Primary liver cancer is one of the most common cancer worldwide. Hepatocellular carcinoma (HCC) in particular, is the second leading cause of cancer deaths in the world. The Hippo signaling pathway has emerged as a major oncosuppressive pathway that plays critical roles inhibiting hepatocyte proliferation, survival, and HCC formation. A key component of the Hippo pathway is the inhibition of yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) transcription factors by the Hippo kinase cascade. Aberrant activation of YAP or TAZ has been found in several human cancers including HCC. It is also well established that YAP/TAZ activation in hepatocytes causes HCC in mouse models, indicating that YAP/TAZ are potential therapeutic targets for human liver cancer. In this review, we summarize the recent findings regarding the multifarious roles of Hippo/YAP/TAZ in HCC development, and focus on their cell autonomous roles in controlling hepatocyte proliferation, differentiation, survival and metabolism as well as their non-cell autonomous in shaping the tumor microenvironment.

scholarly journals RASSF1A-Mediated Regulation of AREG via the Hippo Pathway in Hepatocellular Carcinoma

2013 ◽  
Vol 11 (7) ◽  
pp. 748-758 ◽  
Author(s):  
Ei Yong Ahn ◽  
Ji Su Kim ◽  
Gi Jeong Kim ◽  
Young Nyun Park
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hippo Pathway ◽  
The Hippo Pathway

scholarly journals Fission yeast polycystin Pkd2p promotes transition to cell growth during cytokinesis

2021 ◽  
Author(s):  
Debatrayee Sinha ◽  
Denisa Ivan ◽  
Ellie Gibbs ◽  
Madhurya Chetluru ◽  
John W Goss ◽  
...  
Keyword(s):  
Cell Growth ◽  
Fission Yeast ◽  
Genetic Disorders ◽  
Hippo Pathway ◽  
Cell Stiffness ◽  
Growth Defect ◽  
Temperature Sensitive ◽  
Size Growth ◽  
Autosomal Dominant Polycystic Kidney ◽  
The Hippo Pathway

Polycystins are evolutionally conserved cation channels. Mutations of human polycystins lead to one of the most common genetic disorders, Autosomal Dominant Polycystic Kidney Disorder. Interestingly, the fission yeast homologue Pkd2p is required for cytokinesis the last stage of cell division, but the mechanism remains unclear. Motivated by our discovery of the epistatic genetic interactions between pkd2 and the Hippo pathway Septation Initiation Network (SIN), we investigated their interplay during cytokinesis. We found that pkd2 modulated the localization as well as the activities of SIN. Most notably, pkd2 promotes a transition to cell size growth during cytokinesis, opposed by SIN. The role of Pkd2p in cell growth is not limited to cytokinesis. A newly isolated pkd2 temperature-sensitive mutant largely blocked the tip expansion of cells during interphase. Such growth defect was accompanied by frequent shrinking, reduced cell volume, and decreased cell stiffness. We conclude that Pkd2p promotes transition to the post-mitosis cell growth in coordination with the Hippo pathway

scholarly journals Regulation of Myocardial Cell Growth and Death by the Hippo Pathway

2016 ◽  
Vol 80 (7) ◽  
pp. 1511-1519 ◽  
Author(s):  
Shohei Ikeda ◽  
Junichi Sadoshima
Keyword(s):  
Cell Growth ◽  
Hippo Pathway ◽  
Myocardial Cell ◽  
The Hippo Pathway
Sign in / Sign up

Export Citation Format

Share Document