scholarly journals Effect of HOXA6 on the proliferation, apoptosis, migration and invasion of colorectal cancer cells

2018 ◽  
Author(s):  
Shasha Wu ◽  
Feixiang Wu ◽  
Zheng Jiang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Colorectal Cancer Cells

scholarly journals Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Simona Mareike Lüttgenau ◽  
Christin Emming ◽  
Thomas Wagner ◽  
Julia Harms ◽  
Justine Guske ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Scaffolding Protein ◽  
Migration And Invasion ◽  
Tight Junction Formation ◽  
Cell Metastasis ◽  
Colorectal Cancer Cells

AbstractLoss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals1 is affected in cancer cells and whether Pals1 is implicated in the pathogenesis of the disease.Using mRNA expression data and immunostainings of cancer specimen, we show that Pals1 is frequently downregulated in colorectal cancer, correlating with poorer survival of patients. We further found that Pals1 prevents cancer cell metastasis by controlling Rac1-dependent cell migration through inhibition of Arf6, which is independent of the canonical binding partners of Pals1. Loss of Pals1 in colorectal cancer cells results in increased Arf6 and Rac1 activity, enhanced cell migration and invasion in vitro and increased metastasis of transplanted tumor cells in mice. Thus, our data reveal a new function of Pals1 as a key inhibitor of cell migration and metastasis of colorectal cancer cells. Notably, this new function is independent of the known role of Pals1 in tight junction formation and apical-basal polarity.

LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis

2021 ◽  
Author(s):  
Guo-Qun Chen ◽  
Zhi-Ming Liao ◽  
Jiao Liu ◽  
Fang Li ◽  
Da Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Colorectal Cancer Cells

scholarly journals Upregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression

2013 ◽  
Vol 31 (6) ◽  
pp. 1375-1380 ◽  
Author(s):  
GUANG-JUN ZHANG ◽  
HUA-XU XIAO ◽  
HONG-PENG TIAN ◽  
ZUO-LIANG LIU ◽  
SHU-SEN XIA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Colorectal Cancer Cells

scholarly journals RasGRF2 promotes migration and invasion of colorectal cancer cells by modulating expression of MMP9 through Src/Akt/NF-κB pathway

2018 ◽  
Vol 20 (4) ◽  
pp. 435-443 ◽  
Author(s):  
Peifen Lu ◽  
Junjun Chen ◽  
Lihong Yan ◽  
Lijun Yang ◽  
Litao Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Colorectal Cancer Cells

FAST1 promotes the migration and invasion of colorectal cancer cells

2019 ◽  
Vol 509 (2) ◽  
pp. 407-413 ◽  
Author(s):  
Qiong Cheng ◽  
Yu-jie Shi ◽  
Zhen Li ◽  
Hong Kang ◽  
Zheng Xiang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Colorectal Cancer Cells
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