scholarly journals Altered expression of different GalNAc-transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer

2017 ◽  
Vol 51 (6) ◽  
pp. 1887-1897 ◽  
Author(s):  
Razan Sheta ◽  
Magdalena Bachvarova ◽  
Marie Plante ◽  
Jean Gregoire ◽  
Marie-Claude Renaud ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Disease Progression ◽  
Poor Prognosis ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Altered Expression

CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer

2015 ◽  
Vol 75 (21) ◽  
pp. 4494-4503 ◽  
Author(s):  
Martin Turcotte ◽  
Kathleen Spring ◽  
Sandra Pommey ◽  
Guillaume Chouinard ◽  
Isabelle Cousineau ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Poor Prognosis ◽  
High Grade ◽  
Serous Ovarian Cancer

scholarly journals Low expression of circular RNA hsa_circ_0078607 predicts poor prognosis in high-grade serous ovarian cancer

2020 ◽  
Author(s):  
Nan Zhang ◽  
Zhiyou Yang ◽  
Yue Jin ◽  
Shanshan Cheng ◽  
Jiani Yang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Poor Prognosis ◽  
Cox Regression ◽  
Prognostic Indicator ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Diagnosis And Prognosis ◽  
Low Expression

Abstract Background Ovarian cancer remains one of the most lethal malignancies in women which is typically diagnosed at a late stage and has no effective screening strategy. It is essential to explore novel biomarkers for the diagnosis and prognosis of ovarian cancer, as well as therapeutic targets. Recent studies have shown that circRNAs participate in ovarian cancer progression by regulating various processes and being able to act as potential biomarkers for ovarian cancer diagnosis and prognosis. In the present study we aimed to explore the prognostic role of circ_0078607 in high-grade serous ovarian cancer. Results The expression of circ_0078607 in 49 high-grade serous ovarian cancer and adjacent non-cancerous tissue samples were detected by quantitative real-time polymerase chain reaction (qRT-PCR). We noticed that circ_0078607 expression was significantly downregulated in ovarian cancer tissues compared with adjacent non-cancerous tissues. Besides, patients with low circ_0078607 expression exhibited parameters associated with poor prognosis, including advanced FIGO stage and higher serum CA125 level. Kaplan-Meier survival curve analysis showed that both progression-free survival and overall survival were significantly shortened in patients with low circ_0078607 expression. Cox regression model analysis showed that low expression of circ_0078607 was an adverse prognostic indicator for high-grade serous ovarian cancer patients. Conclusions Low expression of circ_0078607 might be an adverse prognostic indicator for high-grade serous ovarian cancer patients.

CXCL10 alters the tumour immune microenvironment and disease progression in a syngeneic murine model of high-grade serous ovarian cancer

2017 ◽  
Vol 145 (3) ◽  
pp. 436-445 ◽  
Author(s):  
Katrina K. Au ◽  
Nichole Peterson ◽  
Peter Truesdell ◽  
Gillian Reid-Schachter ◽  
Kasra Khalaj ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Disease Progression ◽  
Murine Model ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Immune Microenvironment

scholarly journals PCNA-associated factor P15PAF, targeted by FOXM1, predicts poor prognosis in high-grade serous ovarian cancer patients

2018 ◽  
Vol 143 (11) ◽  
pp. 2973-2984 ◽  
Author(s):  
Chengjuan Jin ◽  
Zhaojian Liu ◽  
Yingwei Li ◽  
Hualei Bu ◽  
Yu Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Associated Factor

Radiomics of high-grade serous ovarian cancer: association between quantitative CT features, residual tumour and disease progression within 12 months

2018 ◽  
Vol 28 (11) ◽  
pp. 4849-4859 ◽  
Author(s):  
Stefania Rizzo ◽  
Francesca Botta ◽  
Sara Raimondi ◽  
Daniela Origgi ◽  
Valentina Buscarino ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Disease Progression ◽  
Residual Tumour ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Quantitative Ct ◽  
Ct Features

scholarly journals Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer

2019 ◽  
Vol 459 ◽  
pp. 1-12 ◽  
Author(s):  
Caroline Kreuzinger ◽  
Isabel von der Decken ◽  
Andrea Wolf ◽  
Magdalena Gamperl ◽  
Julia Koller ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Disease Progression ◽  
Cell Line ◽  
Molecular Mechanisms ◽  
Therapeutic Targets ◽  
Underlying Disease ◽  
High Grade ◽  
Serous Ovarian Cancer

scholarly journals The Capacity of High-Grade Serous Ovarian Cancer Cells to Form Multicellular Structures Spontaneously along Disease Progression Correlates with Their Orthotopic Tumorigenicity in Immunosuppressed Mice

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 699
Author(s):  
Alicia Goyeneche ◽  
Michael-Anthony Lisio ◽  
Lili Fu ◽  
Rekha Srinivasan ◽  
Juan Valdez Capuccino ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Disease Progression ◽  
Therapeutic Interventions ◽  
Ovarian Cancer Cells ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Peritoneal Disease ◽  
Disease Evolution ◽  
Immunosuppressed Mice

Many studies have examined the biology, genetics, and chemotherapeutic response of ovarian cancer’s solid component; its liquid facet, however, remains critically underinvestigated. Floating within peritoneal effusions known as ascites, ovarian cancer cells form multicellular structures, creating a cancer niche in suspension. This study explores the pathobiology of spontaneously formed, multicellular, ovarian cancer structures derived from serous ovarian cancer cells isolated along disease evolution. It also tests their capacity to cause peritoneal disease in immunosuppressed mice. Results stem from an analysis of cell lines representing the most frequently diagnosed ovarian cancer histotype (high-grade serous ovarian cancer), derived from ascites of the same patient at distinct stages of disease progression. When cultured under adherent conditions, in addition to forming cellular monolayers, the cultures developed areas in which the cells grew upwards, forming densely packed multilayers that ultimately detached from the bottom of the plates and lived as free-floating, multicellular structures. The capacity to form foci and to develop multicellular structures was proportional to disease progression at the time of ascites extraction. Self-assembled in culture, these structures varied in size, were either compact or hollow, irregular, or spheroidal, and exhibited replicative capacity and an epithelial nature. Furthermore, they fully recreated ovarian cancer disease in immunosuppressed mice: accumulation of malignant ascites and pleural effusions; formation of discrete, solid, macroscopic, peritoneal tumors; and microscopic growths in abdominal organs. They also reproduced the histopathological features characteristic of high-grade serous ovarian cancer when diagnosed in patients. The following results encourage the development of therapeutic interventions to interrupt the formation and/or survival of multicellular structures that constitute a floating niche in the peritoneal fluid, which in turn halts disease progression and prevents recurrence.

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