scholarly journals Crude extract and solvent fractions of Calystegia soldanella induce G1 and S phase arrest of the cell cycle in HepG2 cells

2017 ◽  
Vol 50 (2) ◽  
pp. 414-420 ◽  
Author(s):  
Jung Im Lee ◽  
In-Hye Kim ◽  
Taek-Jeong Nam
Keyword(s):  
Cell Cycle ◽  
Crude Extract ◽  
Hepg2 Cells ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Nanashara C. de Carvalho ◽  
Sara P. Neves ◽  
Rosane B. Dias ◽  
Ludmila de F. Valverde ◽  
Caroline B. S. Sales ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Ruthenium Complex ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

Antimycin A as a mitochondria damage agent induces an S phase arrest of the cell cycle in HeLa cells

Life Sciences ◽  
2008 ◽  
Vol 83 (9-10) ◽  
pp. 346-355 ◽  
Author(s):  
Yong Hwan Han ◽  
Suhn Hee Kim ◽  
Sung Zoo Kim ◽  
Woo Hyun Park
Keyword(s):  
Cell Cycle ◽  
Hela Cells ◽  
S Phase ◽  
Antimycin A ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Inhibition of tumor cell growth by adenine is mediated by apoptosis induction and cell cycle S phase arrest

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94286-94296 ◽  
Author(s):  
Ming Han ◽  
Xin Cheng ◽  
Zhiqin Gao ◽  
Rongrong Zhao ◽  
Shizhuang Zhang
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
S Phase ◽  
Tumor Cell Growth ◽  
Apoptosis Induction ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals p21Cip1 and p27Kip1Regulate Cell Cycle Reentry after Hypoxic Stress but Are Not Necessary for Hypoxia-Induced Arrest

2001 ◽  
Vol 21 (4) ◽  
pp. 1196-1206 ◽  
Author(s):  
Susannah L. Green ◽  
Rachel A. Freiberg ◽  
Amato J. Giaccia
Keyword(s):  
Cell Cycle ◽  
Dna Synthesis ◽  
Kinase Inhibitors ◽  
S Phase ◽  
Hypoxic Stress ◽  
Cyclin Dependent Kinase ◽  
Low Oxygen ◽  
Double Knockout ◽  
Phase Arrest ◽  
S Phase Arrest

ABSTRACT We investigated the role of the cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 in cell cycle regulation during hypoxia and reoxygenation. While moderate hypoxia (1 or 0.1% oxygen) does not significantly impair bromodeoxyuridine incorporation, at very low oxygen tensions (0.01% oxygen) DNA replication is rapidly shut down in immortalized mouse embryo fibroblasts. This S-phase arrest is intact in fibroblasts lacking the cyclin kinase inhibitors p21Cip1 and p27Kip1, indicating that these molecules are not essential elements of the arrest pathway. Hypoxia-induced arrest is accompanied by dephosphorylation of pRb and inhibition of cyclin-dependent kinase 2, which results in part from inhibitory phosphorylation. Interestingly, cells lacking the retinoblastoma tumor suppressor protein also display arrest under hypoxia, suggesting that pRb is not an essential mediator of this response. Upon reoxygenation, DNA synthesis resumes by 3.5 h and reaches aerobic levels by 6 h. Cells lacking p21, however, resume DNA synthesis more rapidly upon reoxygenation than wild-type cells, suggesting that this inhibitor may play a role in preventing premature reentry into the cell cycle upon cessation of the hypoxic stress. While p27 null cells did not exhibit rapid reentry into the cell cycle, cells lacking both p21 and p27 entered S phase even more aggressively than those lacking p21 alone, revealing a possible secondary role for p27 in this response. Cdk2 activity is also restored more rapidly in the double-knockout cells when returned to normoxia. These studies reveal that restoration of DNA synthesis after hypoxic stress, but not the S phase arrest itself, is regulated by p21 and p27.

Methimazole inhibits FRTL5 thyroid cell proliferation by inducing S-phase arrest of the cell cycle.

Endocrinology ◽  
1993 ◽  
Vol 133 (5) ◽  
pp. 2403-2406 ◽  
Author(s):  
P Smerdely ◽  
V Pitsiavas ◽  
S C Boyages
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
S Phase ◽  
Thyroid Cell ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Cell Cycle Modulation by Marek’s Disease Virus: The Tegument Protein VP22 Triggers S-Phase Arrest and DNA Damage in Proliferating Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100004 ◽  
Author(s):  
Laëtitia Trapp-Fragnet ◽  
Djihad Bencherit ◽  
Danièle Chabanne-Vautherot ◽  
Yves Le Vern ◽  
Sylvie Remy ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Disease Virus ◽  
S Phase ◽  
Tegument Protein ◽  
Proliferating Cells ◽  
Phase Arrest ◽  
Cell Cycle Modulation ◽  
S Phase Arrest ◽  
Protein Vp22

scholarly journals A Cds1-Mediated Checkpoint Protects the MBF Activator Rep2 from Ubiquitination by Anaphase-Promoting Complex/Cyclosome-Ste9 at S-Phase Arrest in Fission Yeast

2009 ◽  
Vol 29 (18) ◽  
pp. 4959-4970 ◽  
Author(s):  
Zhaoqing Chu ◽  
Majid Eshaghi ◽  
Suk Yean Poon ◽  
Jianhua Liu
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Transcriptional Activity ◽  
S Phase ◽  
Anaphase Promoting Complex ◽  
Cell Recovery ◽  
Cycle Progression ◽  
Phase Arrest ◽  
S Phase Arrest

ABSTRACT Transcription of the MluI cell cycle box (MCB) motif-containing genes at G1 phase is regulated by the MCB-binding factors (MBF) (also called DSC1) in Schizosaccharomyces pombe. Upon S-phase arrest, the MBF transcriptional activity is induced through the accumulation of the MBF activator Rep2. In this study, we show that the turnover of Rep2 is attributable to ubiquitin-mediated proteolysis. Levels of Rep2 oscillate during the cell cycle, with a peak at G1 phase, coincident with the MBF activity. Furthermore, we show that Rep2 ubiquitination requires the function of the E3 ligase anaphase-promoting complex/cyclosome (APC/C). Ste9 can be phosphorylated by the checkpoint kinase Cds1 in vitro, and its inhibition/phosphorylation at S-phase arrest is dependent on the function of Cds1. Our data indicate that the Cds1-dependent stabilization of Rep2 is achieved through the inhibition/phosphorylation of APC/C-Ste9 at the onset of S-phase arrest. Stabilization of Rep2 is important for stimulating transcription of the MBF-dependent genes to ensure a sufficient supply of proteins essential for cell recovery from S-phase arrest. We propose that oscillation of Rep2 plays a role in regulation of periodic transcription of the MBF-dependent genes during cell cycle progression.

scholarly journals FAM172A induces S phase arrest of HepG2 cells via Notch 3

2013 ◽  
Vol 29 (3) ◽  
pp. 1154-1160 ◽  
Author(s):  
ZHIQIANG FENG ◽  
HONGQI LI ◽  
SHUNAI LIU ◽  
JUN CHENG ◽  
GUOAN XIANG ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
S Phase ◽  
Notch 3 ◽  
Phase Arrest ◽  
S Phase Arrest
Sign in / Sign up

Export Citation Format

Share Document