scholarly journals Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells

2016 ◽  
Vol 49 (6) ◽  
pp. 2549-2557 ◽  
Author(s):  
Jinbo Liu ◽  
Hongjun Zhu ◽  
Ning Zhong ◽  
Zifeng Jiang ◽  
Lele Xu ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Proliferation And Invasion

scholarly journals KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells

2014 ◽  
Vol 9 (5) ◽  
pp. 1613-1617 ◽  
Author(s):  
FENG LIN ◽  
ZAN SHEN ◽  
LI-NA TANG ◽  
SHUI-ER ZHENG ◽  
YUAN-JUE SUN ◽  
...  
Keyword(s):  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Proliferation And Invasion

scholarly journals Silencing microRNA-27a inhibits proliferation and invasion of human osteosarcoma cells through the SFRP1-dependent Wnt/β-catenin signaling pathway

2019 ◽  
Vol 39 (6) ◽  
Author(s):  
Yu Mu ◽  
Lina Zhang ◽  
Xue Chen ◽  
Si Chen ◽  
Yuanyuan Shi ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Target Gene ◽  
Regulatory Mechanism ◽  
Related Protein ◽  
Related Gene ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Sfrp1 Expression ◽  
Human Osteosarcoma Cells ◽  
Proliferation And Invasion

Abstract Osteosarcoma is the most common malignant tumor of bone with a high potential for metastasis. Importantly, microRNA-27a (miR-27a) is involved in the progression of osteosarcoma. The present study aims to discuss the effects of miR-27a and its target gene secreted frizzled related protein 1 (SFRP1) on proliferation and invasion of human osteosarcoma cells via Wnt/β-catenin signaling pathway. The expression of miR-27a and SFRP1 in osteosarcoma tissues and cells was detected, followed by identification of their relations. Subsequently, miR-27a mimic, miR-27a inhibitor, or siRNA against SFRP1 were introduced into cells (HOS and U2OS) to investigate their role in cell proliferation and invasion. The expression of Wnt/β-catenin signaling pathway-related gene was analyzed to further uncover the regulatory mechanism of miR-27a. The osteosarcoma tissues and cells exhibited elevated miR-27 expression and reduced SFRP1 expression. SFRP1 was verified to be a target gene of miR-27a. Meanwhile, silenced miR-27a inhibited proliferation and invasion of human osteosarcoma cells. Finally, silencing miR-27a inhibited the activation of Wnt/β-catenin signaling pathway, evidenced by reduced β-catenin expression. Our study draws a conclusion that silencing miR-27a dampens osteosarcoma progression, which might be achieved through the inactivation of the Wnt/β-catenin signaling pathway by up-regulating SFRP1.

scholarly journals Gene silencing of NOB1 by lentivirus suppresses growth and migration of human osteosarcoma cells

2014 ◽  
Vol 9 (6) ◽  
pp. 2173-2179 ◽  
Author(s):  
BINGPENG CHEN ◽  
JINGJING LIU ◽  
DANKAI WU ◽  
YANGUO QIN ◽  
CHUANGANG PENG ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
And Migration
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